Protein Alignment Btk and hir-1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_504458.1
• Gene: hir-1 / 178936
• WormBaseID: WBGene00016059
• Length: 903
• Species: Caenorhabditis elegans
• Alignment Length: 327
• Identity: 107/327 - (32%)
• Similarity: 163/327 - (49%)
• Gaps: 51/327 - (15%)

  Fly   510 PTAGLSHDKWEIHPMELMLM--EELGSGQFGVVRRGKWRG--------------------SIDTA 552
            |.....:|.|||....|::.  ::||||.||.|..||..|                    :...|
 Worm   525 PIMAAKNDIWEIERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVA 589

  Fly   553 VKMMKE--GTMSEDDFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR--- 611
            |||:.|  ..||:.:|:.|..:|..| .|..||.:....::..|:.:|.||..:|.||.:||
 Worm   590 VKMLPEYADEMSKHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVEYCDNGDLLKFLRERC 654

  Fly   612 --------------------RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656
                                .::..:|..:..||...:|:|.|:.||.:..::|||:||||.||.
 Worm   655 KYMMKLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVH 719

  Fly   657 SENVVKVADFGLARYVLDD--QYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTC 719
            .....|:.||||.||:..|  ||.|.|| |.|:||..||.:.:..||.|||:|::|:|::|:.|.
 Worm   720 EGTACKIGDFGLCRYIYADQSQYKSKGG-KLPLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITL 783

  Fly   720 GKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTL 784
            |..||..:...:|:..::.|..:|||.:|.:..||||..||:..|::|..|..:..|||...:.:
 Worm   784 GGSPYPGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDRIEFSDVRMQLATQLEDI 848

  Fly   785 TD 786
            |:
 Worm   849 TE 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	100/306 (33%)
hir-1	NP_504458.1	fn3	85..164	CDD:394996
		RGP	227..>281	CDD:385243
		PTKc	547..842	CDD:270623	98/295 (33%)