Protein Alignment Btk and K09B11.5

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001040971.1
• Gene: K09B11.5 / 178307
• WormBaseID: WBGene00010712
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 474
• Identity: 128/474 - (27%)
• Similarity: 207/474 - (43%)
• Gaps: 112/474 - (23%)

  Fly   360 DLSLEKNAE-YEVIDD--SQEHWWKVKDALGNVGYIPSNYVKPKALLGLER---------YEWYV 412
            ||...:|:: ::|..|  |:.|      ::| ...:..||...|    ||.         |.||.
 Worm    25 DLQFGENSDGHQVSSDQLSETH------SIG-ASQVAGNYETEK----LEEMYISHVLKFYPWYH 78

  Fly   413 GDMSRQRAESLLKQGDKEGCFVVRKS---STKGLYTLSLHTKVPQSHVKHYHIKQNAR-CEYYLS 473
            |.|..|..|.|||.   :..::||::   ::|.:..||              :|.:.: |.:.|:
 Worm    79 GMMFGQTVEKLLKW---DYAYLVRRAMQRNSKKVLCLS--------------VKIDGKICHFTLN 126

  Fly   474 EKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSH---DKW-----EIHPM---ELM 527
            .                |..|.:|....:...:..|......|   |.|     .|.|:   :|:
 Worm   127 S----------------NKDGWSCGKLLAKFPKITPKRFQHIHHLLDAWSLVVNSIVPVPRRQLV 175

  Fly   528 LMEE-------LGSGQFGVVRRGKW--RG---SIDTAVKMMKEGTMSED---DFIEEAKVMTKLQ 577
            |...       ||:|.||.|.:.::  ||   .::.|||.: .||...:   :|..||::|..|:
 Worm   176 LQHNCIHLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRV-IGTAQREQMQEFCHEAQIMGTLK 239

  Fly   578 HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN 642
            |.|:|:|||:.|..:||.:|.|.:..|.|..||:  ....|.|..|:. ..:.::.||.:|....
 Worm   240 HDNVVKLYGIASLEQPIMLVMELITGGDLKKYLQ--STPSIPNRQLIA-FALDIANGMRHLVIKK 301

  Fly   643 YIHRDLAARNCLVGSENV-VKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDV 706
            .|||||||||||:....: ||::|||||  |...:......:|.|.:|..||......|:.|:||
 Worm   302 VIHRDLAARNCLISRPTLQVKISDFGLA--VQATEVIVKKLSKAPTRWLAPETFQKGIFNEKTDV 364

  Fly   707 WAYGVLMWEIFT-CGKMPYGRLKNTEVVERVQRGIILEKP------KSCAKEIYDVMKLCWSHGP 764
            |::||::.||.| |...|..    ...:|..:: .|:|.|      ....||:.:::::|.....
 Worm   365 WSFGVVLTEILTRCAADPLA----PRTLEECKK-YIIESPHPHRIENKEPKELAELVEMCCDKNT 424

  Fly   765 EERPAF-------RVLMDQ 776
            ..|..|       ::::||
 Worm   425 MCRANFQNAKRRLKIVIDQ 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	10/41 (24%)
		SH2_Tec_family	403..505	CDD:198188	23/114 (20%)
		PTKc_Tec_like	521..778	CDD:173637	90/289 (31%)
K09B11.5	NP_001040971.1	SH2	74..160	CDD:214585	24/118 (20%)
		TyrKc	181..437	CDD:197581	84/266 (32%)