Protein Alignment Btk and kin-24

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_501761.2
• Gene: kin-24 / 177829
• WormBaseID: WBGene00002206
• Length: 516
• Species: Caenorhabditis elegans
• Alignment Length: 451
• Identity: 119/451 - (26%)
• Similarity: 213/451 - (47%)
• Gaps: 76/451 - (16%)

  Fly   370 EVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFV 434
            |..:.|||     |...|:||....:.:|           .|.|...::...:|:: |::.|.|:
 Worm     5 EACEKSQE-----KTFTGSVGNSRVHNLK-----------CYHGVQKKEEVANLMR-GERPGTFL 52

  Fly   435 VRKSSTKGLYTLSLHTKV------PQSHVKHYHIKQNARCEYYL------------SEKHCCETI 481
            .|....|....|:|...|      ..:::.||.::..|. ||||            .|.....|:
 Worm    53 FRSCFVKSGVALALFLSVKVRAGDSDANIHHYQVEDRAG-EYYLMQELMEKEELVTRESKAFPTL 116

  Fly   482 PDLINYHRHNSGGLACRLK-SSPCDRPVPPTAGLSHDKWEIHPMELMLME--ELGSGQFGVVRRG 543
            .:||.:.:|:.  |||::: ..|..||          .|::....::..:  :||||.|.:|.||
 Worm   117 EELIGHFQHHR--LACKIRLGRPLKRP----------SWQLRHNSVVYDDTGKLGSGNFCIVYRG 169

  Fly   544 KWRGS---IDTAVKMMKEGTMSEDDFIE-------EAKVMTKLQHPNLVQLYGVCSKHRPIYIVT 598
            ..|..   |..|:|:.|.........:|       ||::|....:.|::::|||.....|..:..
 Worm   170 MLRKQGKIIPVAIKVSKNSDKESAALMETRNLLLAEARIMMNYNNINVIRIYGVACDVPPFMVCM 234

  Fly   599 EYMKHGSLLNYLRRHEKTL--IGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVV 661
            |:...|||.:.|:::.|.:  .....||:|    .::||.||.....:|||||:||||:..:.:|
 Worm   235 EFCSGGSLEDALKKYGKDMEEFERQILLID----AARGMRYLHDKKCVHRDLASRNCLISFDGIV 295

  Fly   662 KVADFGLARYVLDDQYTSSGGTK-FPIKWAPPE-VLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY 724
            |:|||||::.:..||.......| .|:.|..|| :...:.||:|:||||:||:::|::...:..:
 Worm   296 KIADFGLSKTLEKDQKAFKEALKEAPLAWLAPECIQRESEFSTKTDVWAFGVVIFEVYNNAEKLF 360

  Fly   725 GRLKNTEVVERVQRG---IILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL--ALV 780
            ...::..::.::::.   .|..:.|..|.:.  |:...|:..|::||..:.::::|  |||
 Worm   361 AGEEDIAILRKIKKANMPTIENRTKVPAMQA--VLSSIWTRKPDDRPEMQKVLEKLVAALV 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	8/28 (29%)
		SH2_Tec_family	403..505	CDD:198188	27/120 (23%)
		PTKc_Tec_like	521..778	CDD:173637	77/277 (28%)
kin-24	NP_501761.2	SH2	29..128	CDD:214585	23/102 (23%)
		STYKc	157..414	CDD:214568	76/262 (29%)