DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and C55C3.4

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_500846.1 Gene:C55C3.4 / 177346 WormBaseID:WBGene00016954 Length:431 Species:Caenorhabditis elegans


Alignment Length:379 Identity:117/379 - (30%)
Similarity:192/379 - (50%) Gaps:42/379 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   409 EWYVGDMSRQRAESLLKQGDKEGCFVVRKS----STKGLYTLSLHTKVPQSHVKHYH-IKQNARC 468
            ::|.|.:.|:..:.:|   :|.|.|::|.|    ..|..:.||:   |.:.:....| :.:.|..
 Worm    10 KYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSV---VGEKNTSANHFVVREADH 68

  Fly   469 EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSH----DKWEIHPMELMLM 529
            :.|: :|....||.:|:|::      ::.:...|..|..|...  |.|    .|||::..::.|.
 Worm    69 KVYV-DKIGFPTIIELVNHY------VSTKESFSTKDGTVKVV--LKHAVERQKWELYHEDVELT 124

  Fly   530 EELGSGQFGVVRRGKWRGSID-------TAVKMMKEGTMSED---DFIEEAKVMTKLQHPNLVQL 584
            ::||.|.||.|.:||....:|       .|||..|..:|:::   :.:.||::|..|.|.|:|:.
 Worm   125 KKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVVKF 189

  Fly   585 YGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLA 649
            :||.:...|:|::.|....|:|.:.|.:....:|....|:    .|.:.|:.|:...|.:|||:|
 Worm   190 FGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELI----YQAANGLAYIHEKNLMHRDVA 250

  Fly   650 ARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMW 714
            |||||.|. ..||:|||||:|...|  ||.....|.||:|.|||.:....::.|:||:|:||:.|
 Worm   251 ARNCLYGG-GQVKIADFGLSREGAD--YTMDLKKKVPIRWLPPETIRSGLYTPKTDVFAFGVMAW 312

  Fly   715 EIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYD-VMKLCWSHGPEER 767
            ||...||.||...|..||..:|.:|..:.......||..: ::..||....|:|
 Worm   313 EITEDGKEPYPGFKVIEVAMKVLQGYRMPFSPEVNKEFAEFILTKCWPEKYEDR 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 22/100 (22%)
PTKc_Tec_like 521..778 CDD:173637 88/258 (34%)
C55C3.4NP_500846.1 SH2_Fps_family 4..93 CDD:198224 21/95 (22%)
TyrKc 121..376 CDD:197581 88/253 (35%)
Blue background indicates that the domain is not in the aligned region.

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