DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and R05H5.4

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_496201.1 Gene:R05H5.4 / 174581 WormBaseID:WBGene00011039 Length:414 Species:Caenorhabditis elegans


Alignment Length:421 Identity:119/421 - (28%)
Similarity:194/421 - (46%) Gaps:79/421 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   381 KVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYT 445
            |:.:|..|:.|...      ||:.::             |:.||.   .||.|:|.......:..
 Worm     6 KLSEADANLPYFHG------ALMNID-------------ADQLLV---NEGDFMVTMKKQLDINK 48

  Fly   446 LSLHTKVP-QSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCD---- 505
            |.|...|. :..::.|.||:.::......:  ..:.|..|||           .||:.|.:    
 Worm    49 LQLFLAVRLKKGIRRYEIKRTSKTAKIGGK--TSQNIVKLIN-----------MLKADPIEIRGE 100

  Fly   506 -----RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDT-AVKMMKEGTMSED 564
                 |.:|      ..|:::...:::..:::|:|.:|.|.|||...:.:. |||.:......||
 Worm   101 KVVLKRAIP------KGKFQLMHKDVIFQKKIGAGAYGTVYRGKLVKTDEVIAVKKLDPEGADED 159

  Fly   565 ---DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR-RHEKTLIGNMGLLL 625
               :.::||:||....|||:|:.:|......|..:|.||...|::.:.|| :.||..:...   :
 Worm   160 GLAEMMKEARVMQLYDHPNIVKFHGFILDDLPYLLVLEYCNGGAVEDRLRDKGEKIKVPTR---V 221

  Fly   626 DMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR----YVLDDQYTSSGGTKFP 686
            ......:.||.||.:.|.||||:|:||||: .:.|||:||||:.|    |.:|        .|.|
 Worm   222 KYTYMAACGMDYLHKKNCIHRDIASRNCLI-HKGVVKMADFGMCRAQSVYKVD--------LKKP 277

  Fly   687 --IKWAPPEVLN--YTRFSSKSDVWAYGVLMWEIF-TCGKMPYGRLKNTEVVERVQRGIILEKPK 746
              |:|..|||.:  .|||:  :||:|:|::|||.| |..|.||..:|..:|..:.:.|..|..|.
 Worm   278 CNIRWLAPEVWDNGETRFN--TDVYAFGIMMWEFFETPFKSPYVEMKAAQVKRKTRAGYRLPPPP 340

  Fly   747 SCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |....:.::|..||....|:||....|.::|
 Worm   341 SMPSRMVEIMSECWQVDAEKRPTAEELKEKL 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 4/17 (24%)
SH2_Tec_family 403..505 CDD:198188 20/102 (20%)
PTKc_Tec_like 521..778 CDD:173637 90/271 (33%)
R05H5.4NP_496201.1 SH2_Fps_family 9..97 CDD:198224 25/122 (20%)
TyrKc 120..363 CDD:197581 87/256 (34%)
Blue background indicates that the domain is not in the aligned region.

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