DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and src-2

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_493502.1	Gene:	src-2 / 173296	WormBaseID:	WBGene00005078	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	189/512 - (36%)
Similarity:	288/512 - (56%)	Gaps:	47/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 GSC------TPTSLQP-QSSLTTFKQS-----------PTLLNGNGTLLDANMPGGIPTPGTPNS 335
            |||      .|.:..| .:|.|..::|           |...:.:|..:|            .|.
Worm     2 GSCIGKEDPPPGATSPVHTSSTLGRESLPSHPRIPSIGPIAASSSGNTID------------KNQ 54

  Fly   336 KAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK-DALGNVGYIPSNYVKP 399
            ....:::|    |||:.:.|....|||.:|:...|:::|:|..||..: .|.|..||||||||..
Worm    55 NISQSANF----VALFQYDARTDDDLSFKKDDILEILNDTQGDWWFARHKATGRTGYIPSNYVAR 115

  Fly   400 KALLGLERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIK 463
            :.  .:|...||.|.|.|..||. ||...::.|.|:||.|.:: .:.|||..:...| ||||.|:
Worm   116 EK--SIESQPWYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESR-QHDLSLSVRENDS-VKHYRIR 176

  Fly   464 QNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDR-PVPPTAGLSH-DKWEIHPMEL 526
            |.....|:::.:....|:.|||.:::..:.||...| .:||.: ..|.|...:: |:||:....:
Worm   177 QLDHGGYFIARRRPFATLHDLIAHYQREADGLCVNL-GAPCAKSEAPQTTTFTYDDQWEVDRRSV 240

  Fly   527 MLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591
            .|:.::|:||||.|..|:|..::..|||.:|.||....||:.||::|.||:||.|:.||.||::.
Worm   241 RLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRD 305

  Fly   592 RPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVG 656
            .||.||||.|:. :||.:|:|..:..  .|..|:::..||:.||.|||..|:|||||||||.|:.
Worm   306 EPILIVTELMQE-NLLTFLQRRGRQC--QMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILIN 367

  Fly   657 SENVVKVADFGLARYVL-DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCG 720
            :...||:|||||||.:: :::|.:..|.:|||||..||..||.||::|||||::|:|:.||.|.|
Worm   368 NSLSVKIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFG 432

  Fly   721 KMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ::||..:.|.||:::|..|..:..|..|...:||:|:.||...|::||.|..|..:|
Worm   433 RLPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	23/53 (43%)
		SH2_Tec_family	403..505	CDD:198188	34/102 (33%)
		PTKc_Tec_like	521..778	CDD:173637	113/258 (44%)
		Pkinase_Tyr	526..777	CDD:285015	112/251 (45%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	21/54 (39%)
		SH2_Src_Src42	120..215	CDD:198233	33/97 (34%)
		PTKc_Frk_like	231..496	CDD:270653	116/262 (44%)
		Pkinase_Tyr	240..489	CDD:285015	112/251 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820