DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and C35E7.10

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_492826.1 Gene:C35E7.10 / 172988 WormBaseID:WBGene00016462 Length:430 Species:Caenorhabditis elegans


Alignment Length:381 Identity:113/381 - (29%)
Similarity:189/381 - (49%) Gaps:46/381 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   409 EWYVGDMSRQRAESLLKQGDKEGCFVVRKS----STKGLYTLSLHTKVPQSHVKHYHIKQNARCE 469
            ::|.|.:.|:..:.:|   :|.|.|::|.|    ..|..:.||: ....::...|:.::::....
 Worm    10 KYYHGLLPREDIQEML---NKPGQFLLRTSEPVKGEKRQFVLSV-VGEKKTSANHFVVRESDHKV 70

  Fly   470 YYLSEKHCCETIPDLINYH-------RHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELM 527
            |.  :|....||.:|:|::       ....|.:...||.:           :...|||::..::.
 Worm    71 YV--DKIGFPTIIELVNHYVSTKESFSTKDGTVKAVLKQA-----------VERQKWELYHEDVE 122

  Fly   528 LMEELGSGQFGVVRRGKWRGSID-------TAVKMMKEGTMSED---DFIEEAKVMTKLQHPNLV 582
            |.::||.|.||.|.:||....:|       .|||..|..:|:::   :.:.||::|..|.|.|:|
 Worm   123 LTKKLGEGAFGEVWKGKLLKILDANHQPVLVAVKTAKLESMTKEQIKEIMREARLMRNLDHINVV 187

  Fly   583 QLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRD 647
            :.:||.:...|:|::.|....|:|.:.|.:....:|....|:    .|.:.|:.|:...|.:|||
 Worm   188 KFFGVAAGTEPLYVIMELADGGALDSALGKLHFPMIKKYELI----YQAANGLAYIHEKNLMHRD 248

  Fly   648 LAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVL 712
            :||||||.|. ..||:|||||:|...|  ||.....|.||:|.|||.:....::.|:||:|:||:
 Worm   249 VAARNCLYGG-GQVKIADFGLSREGAD--YTMDLKKKVPIRWLPPETIRSGLYTPKTDVFAFGVM 310

  Fly   713 MWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYD-VMKLCWSHGPEER 767
            .|||...||.||...|..||..:|.:|..:.......||..: ::..||....|:|
 Worm   311 AWEITEDGKEPYPGFKVIEVAMKVLQGYRMPFSPEVNKEFAEFILTKCWPEKYEDR 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 22/106 (21%)
PTKc_Tec_like 521..778 CDD:173637 88/258 (34%)
C35E7.10NP_492826.1 SH2_Fps_family 4..93 CDD:198224 19/88 (22%)
TyrKc 121..376 CDD:197581 88/253 (35%)
Blue background indicates that the domain is not in the aligned region.

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