Protein Alignment Btk and F26E4.5

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_492594.2
• Gene: F26E4.5 / 172828
• WormBaseID: WBGene00009160
• Length: 474
• Species: Caenorhabditis elegans
• Alignment Length: 487
• Identity: 137/487 - (28%)
• Similarity: 230/487 - (47%)
• Gaps: 91/487 - (18%)

  Fly   299 QSSLTTFKQSPTLL---------NGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFK 354
            :|.:.|..:.|.||         :|..|.|..::....|.....||....:.|.:|
 Worm    14 RSEVETAVRGPDLLLKATDETSSDGASTSLSKSVEESAPNKDKSNSSLVKSHHVLK--------- 69

  Fly   355 AIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQR 419
                  :.|:|..          :|.....||                  |:...:|.|.|||:.
 Worm    70 ------IKLKKIT----------NWSGCSGAL------------------LDDEPFYHGYMSREE 100

  Fly   420 AESLLKQGDKEGCFVVRKSS-TK--GLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETI 481
            :|.|::   .:|.|::||:. ||  .:..||:..   ...|.|..:::.....|||.| .|.|.|
 Worm   101 SEKLVR---SQGEFLLRKTELTKRGEVVVLSVFW---DEGVHHLVVEKANNGLYYLKE-FCFENI 158

  Fly   482 PDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQF-----GVVR 541
            .||:.||.        :.::|.....:...:.:..::|:::..::.|.::||:|:|     ||:.
 Worm   159 SDLVRYHH--------QTRASVYKSGIKLFSWVVREEWQLYHEQINLGKKLGNGEFGEVFQGVLS 215

  Fly   542 RGKWRGSIDTAVKMMKEGTMSEDD---FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKH 603
            .|.:...::.|||.||...::.|:   |:.||.:|.||.|..:|:||||.::..||.||.|....
 Worm   216 VGIFTNDVEVAVKTMKGSKVTADERITFLREANLMLKLNHKYVVRLYGVATQQEPIMIVMELCSG 280

  Fly   604 GSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGL 668
            |.|.:.:.:.::.|  :..|....|.|::|||.|||:...|||||||||.|:...:..|::||||
 Worm   281 GCLKSRIEKKDEQL--SDVLKRKYCKQIAKGMRYLEKKQVIHRDLAARNVLLDKSDNCKISDFGL 343

  Fly   669 ARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVV 733
            :  :....:......|.||:|..||.|....:|||||||::||:|:|:|: |:.||..:|   |:
 Worm   344 S--LFGKLHKEQKLMKVPIRWLAPETLLKGIYSSKSDVWSFGVVMFEVFS-GEYPYADVK---VL 402

  Fly   734 ERVQRGII-----LEKPKSCAKEIYDVMKLCW 760
            :.::|.:.     |:.|.....:...||::|:
 Worm   403 KELRRKVAHENLRLKPPSDMPTDDAKVMEMCF 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	5/52 (10%)
		SH2_Tec_family	403..505	CDD:198188	30/104 (29%)
		PTKc_Tec_like	521..778	CDD:173637	88/253 (35%)
F26E4.5	NP_492594.2	SH2_Fps_family	86..172	CDD:198224	29/100 (29%)
		TyrKc	195..449	CDD:197581	88/248 (35%)