DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and kin-14

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_492004.1 Gene:kin-14 / 172440 WormBaseID:WBGene00002198 Length:418 Species:Caenorhabditis elegans


Alignment Length:417 Identity:129/417 - (30%)
Similarity:208/417 - (49%) Gaps:75/417 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   409 EWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKH----YHIKQNARC- 468
            ||:.|.:.||.|:.||.   |.|.|::|.|...|..::.|       .|:|    ::|..|:.. 
 Worm    29 EWFHGVLQRQDADELLV---KPGSFLLRASEVHGKMSMIL-------SVRHDGKLHNIAVNSDTG 83

  Fly   469 EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAG------LSHDKWEIHPMELM 527
            |.:..|.|..::|..|:.:|...|             .|:..|:|      :....|.|....::
 Worm    84 ENFWFEGHREKSIDQLVQWHMTTS-------------TPITKTSGVKLKYPIGKADWIISHENVI 135

  Fly   528 LMEELGSGQFGVVRRGKWR---GSIDTAVKMMKEGTMSEDD---FIEEAKVMTKLQHPNLVQLYG 586
            .:::||.|.||.|...:..   ..::||||.|: ..|:.|.   |::||::|.|..||::|::.|
 Worm   136 FIKKLGEGAFGEVSLAECEIGGRKVETAVKTMR-CQMTRDTRAAFMKEARLMRKYSHPHIVRIIG 199

  Fly   587 -VCSKH----------RPIYIVTEYMKHGSLLNYLRRHE-KTLIGNMGLLLDMCIQVSKGMTYLE 639
             :..||          .|:.||.|...|||||::||::: ||.:...   |..||:.:.|:.|||
 Worm   200 KIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSFLRKNKGKTTLSER---LRFCIESADGLAYLE 261

  Fly   640 RHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGG---TKFPIKWAPPEVLNYTRFS 701
            :...:|||:||||||:...:.:|::||||:    ||:.|....   .|.|:||..|||:....:|
 Worm   262 KKQCLHRDIAARNCLLSITDQIKISDFGLS----DDKRTEMHDDTLDKVPVKWLAPEVMQDKLYS 322

  Fly   702 SKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGII------LEKPKSCAKEIYDV-MKLC 759
            .||||||:|||||||:..|..||..:.|.     |.|..|      :..|::....|.:: :|.|
 Worm   323 LKSDVWAFGVLMWEIYADGADPYPGMTNL-----VTRAKIFCDDYRMTFPETTPPTISEIALKQC 382

  Fly   760 WSHGPEERPAFRVLMDQLALVAQTLTD 786
            |:..|.:|...:.:..:|..::..::|
 Worm   383 WAKLPSDRATMKTVHHKLKDLSMPMSD 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 26/100 (26%)
PTKc_Tec_like 521..778 CDD:173637 97/284 (34%)
kin-14NP_492004.1 SH2_Fps_family 26..110 CDD:198224 26/103 (25%)
PTKc 138..401 CDD:270623 96/275 (35%)
Blue background indicates that the domain is not in the aligned region.

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