Protein Alignment Btk29A and src-1

DIOPT Version :9

• Sequence 1: NP_001097121.1
• Gene: Btk29A / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001364829.1
• Gene: src-1 / 171722
• WormBaseID: WBGene00005077
• Length: 537
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 214/583 - (36%)
• Similarity: 302/583 - (51%)
• Gaps: 92/583 - (15%)

  Fly   216 GCRAAAHWREANNNPSNGSSPAQNSTRSIS--PNSSTTNSQFSLQH-NSSGSLG-----GGVGGG 272
            ||..:...|      |.||....:....:|  |....|..|.::.| |:.|:.|     .|...|
 Worm     2 GCLFSKERR------SGGSDMGVSERIDVSRYPRRFQTPQQQTVFHVNNGGNEGTISQLNGTSDG 60

  Fly   273 LGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKA 337
            :.|.|.    |||||||:               ::..||
 Worm    61 MMGNGR----GGGGGGGA---------------QERETL-------------------------- 80

  Fly   338 KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK-DALGNVGYIPSNYVKPKA 401
                      |||||:.:...||||.:|.....::|.|...||.|: ...|..||:|.|:|..:.
 Worm    81 ----------VALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQ 135

  Fly   402 LLGLERYEWYVGDMSRQRAESL-LKQGDKEGCFVV--RKSSTKGLYTLSLHTKVPQSH---VKHY 460
            .  :|..|||.|.:.|.|||.| |.....:|.|::  |::.|:. :.|::.....|.:   ||||
 Worm   136 T--IESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTRE-FALTIRDTDDQRNGGTVKHY 197

  Fly   461 HIKQNARCE-YYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHD---KWEI 521
            .||:....: |:::.:....::.:|:.|:.....||.|:| :.|..|..|....||||   .|||
 Worm   198 KIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQL-TFPAPRLAPTRPDLSHDTQQNWEI 261

  Fly   522 HPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYG 586
            ...:|.|..:||.|.||.|..|||||.::.|:|.||.||||.:.|::||::|.:..|||||:||.
 Worm   262 PRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYA 326

  Fly   587 VCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAAR 651
            ||::..|.||:||||.:||||.|||....||  .:..|:||..|::.||.|||....:|||||||
 Worm   327 VCTREEPFYIITEYMINGSLLQYLRTDGSTL--GIQALVDMAAQIANGMMYLEERKLVHRDLAAR 389

  Fly   652 NCLVGSE----NVVKVADFGLARYVL-DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGV 711
            |.|||.:    .|||||||||||.:: :|.|.:..|.||||||..||......|:.|||||:||:
 Worm   390 NVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGI 454

  Fly   712 LMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIY-DVMKLCWSHGPEERPAFRVL 773
            |::||.|.|::||..:.|.||||:|:.|..:..|:.|.::|| :|:..||...|:.||.|..|
 Worm   455 LLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTL 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	2/5 (40%)
		SH3_Tec_like	346..399	CDD:212702	21/53 (40%)
		SH2_Tec_family	403..505	CDD:198188	31/108 (29%)
		PTKc_Tec_like	521..778	CDD:173637	127/259 (49%)
		Pkinase_Tyr	526..777	CDD:285015	126/254 (50%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779	21/86 (24%)
		SH2_Src_family	138..240	CDD:199827	30/103 (29%)
		PTKc_Src_like	270..522	CDD:270630	124/250 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820