Protein Alignment Btk and spe-8

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_490680.1
• Gene: spe-8 / 171606
• WormBaseID: WBGene00004962
• Length: 512
• Species: Caenorhabditis elegans
• Alignment Length: 537
• Identity: 138/537 - (25%)
• Similarity: 229/537 - (42%)
• Gaps: 124/537 - (23%)

  Fly   294 TSLQPQSSLTTFKQSPTLLNGNGT-LLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIE 357
            |..:..::|....::|..|....| |..|..|...|.|..|...:.||::..:|
 Worm    35 TQKERNAALDNLAKTPIQLVVQPTPLTPAITPCEAPPPPPPPKPSSDNNNSKRL----------- 88

  Fly   358 GGDLSLEKNAEYEVIDDSQEHWWKVKDAL-----GNVGYIPSNYVKPKALLGLERYEWYVGDMSR 417
                                   ||||.|     ..||.:.:|         ::.:.:|.|.|.|
 Worm    89 -----------------------KVKDQLIEVPSDEVGRVENN---------IDNFPFYHGFMGR 121

  Fly   418 QRAESLLKQGDKEGCFVVRKS--STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCET 480
            ...|::|   ...|.|::|.:  ..:..|.:|:..|....||.   :|:....:.|.::|:..::
 Worm   122 NECEAML---SNHGDFLIRMTEIGKRVAYVISIKWKYQNIHVL---VKRTKTKKLYWTKKYAFKS 180

  Fly   481 IPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKW 545
            |.:||.||:.|         ..|....:....||:...|:::..::.|.::||.||||.|.:|..
 Worm   181 ICELIAYHKRN---------HKPIYEGMTLICGLARHGWQLNNEQVTLNKKLGEGQFGEVHKGSL 236

  Fly   546 RGS-----IDTAVKMMKEGTMSEDD---FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMK 602
            :.|     :..|||.:.:..:|.::   |:.||.||..|.|||:::.||||:...||.||.|:..
 Worm   237 KTSVFAAPVTVAVKTLHQNHLSANEKILFLREANVMLTLSHPNVIKFYGVCTMKEPIMIVMEFCD 301

  Fly   603 HGSLLN-YLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADF 666
            ..||.: .|.:.||....:..|.|   ...:.|:.||.....||||:||||||:.|:.::|::||
 Worm   302 GKSLEDALLSKEEKVSAEDKILYL---FHAACGIDYLHGKQVIHRDIAARNCLLNSKKILKISDF 363

  Fly   667 GLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY------- 724
            ||:  |.........|...|:|:..||.|....:|:.||:::||.||:|::|.||.|:
 Worm   364 GLS--VKGVAIKERKGGCLPVKYMAPETLKKGLYSTASDIYSYGALMYEVYTDGKTPFETCGLRG 426

  Fly   725 GRLKNTEVVERVQRGIILEKP-----------------KSCAKEIYDVMK--------------- 757
            ..|:...:.:|:...:.:|.|                 :..:|:|..:.|
 Worm   427 NELRKAIIGKRISLAVEVELPVFIANIFEQSRQYETEDRISSKQIIQIFKEEVGFHEIETSGILH 491

  Fly   758 -----LCWSHGPEERPA 769
                 |...|..|.:||
 Worm   492 KLVNSLPRIHNKERKPA 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	9/57 (16%)
		SH2_Tec_family	403..505	CDD:198188	24/103 (23%)
		PTKc_Tec_like	521..778	CDD:173637	89/302 (29%)
spe-8	NP_490680.1	SH2_Fps_family	109..195	CDD:198224	23/100 (23%)
		PTKc	221..476	CDD:270623	82/259 (32%)