DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Lck

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001155904.1	Gene:	Lck / 16818	MGIID:	96756	Length:	520	Species:	Mus musculus

Alignment Length:	464	Identity:	193/464 - (41%)
Similarity:	280/464 - (60%)	Gaps:	33/464 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 GGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGN 388
            |.:|    |.|..:||     ||:||:.::....|||..||..:..:::.|.| |||.:. ..|.
Mouse    64 GSLP----PASPLQDN-----LVIALHSYEPSHDGDLGFEKGEQLRILEQSGE-WWKAQSLTTGQ 118

  Fly   389 VGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLHTK 451
            .|:||.|:| .|| ..||...|:..::||:.|| .||..|:..|.|::|:| ||.|.::||:. .
Mouse   119 EGFIPFNFV-AKA-NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVR-D 180

  Fly   452 VPQSH---VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC--DRPVPPT 511
            ..|:.   ||||.|:......:|:|.:.....:.||:.::.:.|.||..:| |.||  .:|..|
Mouse   181 FDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKL-SRPCQTQKPQKP- 243

  Fly   512 AGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKL 576
              ...|:||:....|.|:|.||:||||.|..|.:.|....|||.:|:|:||.|.|:.||.:|.:|
Mouse   244 --WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL 306

  Fly   577 QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIG---NMGLLLDMCIQVSKGMTYL 638
            |||.||:||.|.:: .||||:||||::|||:::|    ||..|   |:..||||..|:::||.::
Mouse   307 QHPRLVRLYAVVTQ-EPIYIITEYMENGSLVDFL----KTPSGIKLNVNKLLDMAAQIAEGMAFI 366

  Fly   639 ERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSK 703
            |..|||||||.|.|.||......|:|||||||.:.|::||:..|.||||||..||.:||..|:.|
Mouse   367 EEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 431

  Fly   704 SDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERP 768
            ||||::|:|:.||.|.|::||..:.|.||::.::||..:.:|.:|.:|:|.:|.|||...||:||
Mouse   432 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRP 496

  Fly   769 AFRVLMDQL 777
            .|..|...|
Mouse   497 TFDYLRSVL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	20/53 (38%)
		SH2_Tec_family	403..505	CDD:198188	36/108 (33%)
		PTKc_Tec_like	521..778	CDD:173637	124/260 (48%)
		Pkinase_Tyr	526..777	CDD:285015	123/253 (49%)
Lck	NP_001155904.1	SH3_Lck	76..129	CDD:212938	20/54 (37%)
		SH2_Src_Lck	134..234	CDD:198225	33/101 (33%)
		PTKc_Lck_Blk	248..511	CDD:270652	126/263 (48%)
		Pkinase_Tyr	256..505	CDD:285015	123/253 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820