DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk and Jak3

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_034719.2 Gene:Jak3 / 16453 MGIID:99928 Length:1100 Species:Mus musculus


Alignment Length:312 Identity:100/312 - (32%)
Similarity:144/312 - (46%) Gaps:51/312 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   510 PTAGLSHDKWEI---------------HPMELMLMEELGSGQFGVVR------RGKWRGSIDTAV 553
            ||.|:...:.|:               ....|..:..||.|.||.|.      .|...|.:....
Mouse   787 PTPGIPSPRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVK 851

  Fly   554 KMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVC--SKHRPIYIVTEYMKHGSLLNYLRRHEKT 616
            ::...|...:.||..|.:::..|....:|:..||.  ...:.:.:|.||:..|.|.::|:||...
Mouse   852 QLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR 916

  Fly   617 LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL--DDQYTS 679
            |  :...||....|:.|||.||.....:||||||||.||.||..||:||||||:.:.  .|.|..
Mouse   917 L--HTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVV 979

  Fly   680 SGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CGKM------------------PYG 725
            ....:.||.|..||.|:...||.:||||::||:::|:|| |.|.                  |..
Mouse   980 REPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLSMMGPEREGPPLC 1044

  Fly   726 RLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ||     :|.:..|..|..|.:|..|:.::|:|||:..|.:||||..|..||
Mouse  1045 RL-----LELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQL 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188
PTKc_Tec_like 521..778 CDD:173637 96/301 (32%)
Jak3NP_034719.2 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..223
FERM_F1 41..114 CDD:465733
FERM_B-lobe 126..245 CDD:481193
FERM_C_JAK3 250..359 CDD:275413
SH2 359..455 CDD:472789
Protein Kinases, catalytic domain 517..774 CDD:473864
Protein Kinases, catalytic domain 813..1095 CDD:473864 96/286 (34%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.