DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk29A and Jak2

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001041642.1 Gene:Jak2 / 16452 MGIID:96629 Length:1132 Species:Mus musculus


Alignment Length:290 Identity:98/290 - (33%)
Similarity:155/290 - (53%) Gaps:32/290 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   517 DKWEIHPMELMLMEELGSGQFGVVRRGKW------RGSIDTAVKMMKEGTMSE-DDFIEEAKVMT 574
            |..:.....|..:::||.|.||.|...::      .|.: .|||.::..|... .||..|.:::.
Mouse   840 DPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEV-VAVKKLQHSTEEHLRDFEREIEILK 903

  Fly   575 KLQHPNLVQLYGVC--SKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTY 637
            .|||.|:|:..|||  :..|.:.::.||:.:|||.:||::|::.:  :...||....|:.|||.|
Mouse   904 SLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERI--DHKKLLQYTSQICKGMEY 966

  Fly   638 LERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSSGGTKFPIKWAPPEVLNYTRF 700
            |....|||||||.||.||.:||.||:.||||.:.:..|:  |......:.||.|..||.|..::|
Mouse   967 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKF 1031

  Fly   701 SSKSDVWAYGVLMWEIFT---------------CGKMPYGRLKNTEVVERVQRGIILEKPKSCAK 750
            |..||||::||:::|:||               .|....|::....::|.::....|.:|:.|..
Mouse  1032 SVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPD 1096

  Fly   751 EIYDVMKLCWSHGPEERPAFRVL---MDQL 777
            |||.:|..||::...:||:||.|   :||:
Mouse  1097 EIYVIMTECWNNNVSQRPSFRDLSLRVDQI 1126

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188
PTKc_Tec_like 521..778 CDD:173637 97/286 (34%)
Pkinase_Tyr 526..777 CDD:285015 96/279 (34%)
Jak2NP_001041642.1 Interaction with cytokine/interferon/growth hormone receptors 1..239
FERM_F1 39..134 CDD:408179
FERM_F2 143..261 CDD:408177
FERM_C_JAK2 266..386 CDD:270141
SH2_Jak2 386..482 CDD:198242
PTK_Jak2_rpt1 545..806 CDD:270663
PTKc_Jak2_rpt2 844..1127 CDD:271107 97/286 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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