Protein Alignment Btk and Jak1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_666257.2
• Gene: Jak1 / 16451
• MGIID: 96628
• Length: 1153
• Species: Mus musculus
• Alignment Length: 1019
• Identity: 212/1019 - (20%)
• Similarity: 331/1019 - (32%)
• Gaps: 397/1019 - (38%)

  Fly     4 TKHRNSHVNGSIKSSSSLRSSSKSFQAKMDLMSER--------------LYDVVKSGSM------ 48
            |||..:.:                |:..|.|:|..              ||:|:.:|::
Mouse   278 TKHYGAEI----------------FETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQ 326

  Fly    49 ------VKRAQNKKRFTPVNY-KHR-----------WFELTKRTFSYF----------------- 78
                  |::.:||.:...:.| ||:           |     ..||||
Mouse   327 KPNVVPVEKEKNKLKRKKLEYNKHKKDDERNKLREEW-----NNFSYFPEITHIVIKESVVSINK 386

  Fly    79 -DVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANS--------- 133
             |.:|:|.:.......|..|.||:                     ||..::|.|:.
Mouse   387 QDNKNMELKLSSREEALSFVSLVD---------------------GYFRLTADAHHYLCTDVAPP 430

  Fly   134 ---HQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYH 195
               |.::||..|               |..|.|.|....:|.||
Mouse   431 LIVHNIQNGCHG---------------PICTEYAINKLRQEGSE--------------------- 459

  Fly   196 PGLWSGKKWSC-----------CKGLSRTTFGCRAAAHWR---EANNNPSNGSSPAQNSTRSISP 246
            .|::. .:|||           |...|....|.:...:::   :......:||.....|.|.:..
Mouse   460 EGMYV-LRWSCTDFDNILMTVTCFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMN 523

  Fly   247 NSS-----TTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFK 306
            :..     |.|..|.|:.                              .|.|...:..:.|...|
Mouse   524 HLKKQILRTDNISFVLKR------------------------------CCQPKPREISNLLVATK 558

  Fly   307 QS-------------------PTLLNG------------NGTLLDANMPGGIPTPGTPNSKAK-- 338
            ::                   ..::.|            :|||||.....||    ....|.|
Mouse   559 KAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDEEGI----AEEKKIKVI 619

  Fly   339 ----DNSH------FV-----------KLVVALYPF-----------KAIEGGDLSLEKNAEYEV 371
                |.||      |.           |.:|.||..           :.:|||.|.|..:.:.:.
Mouse   620 LKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDA 684

  Fly   372 IDDSQEHWWKVKDA---------LGNVGYIPSNYVKPKALLGLERYEWYVGD------------- 414
            :...    ||.|.|         |.:...:..|......||..|..:..:|.
Mouse   685 LTTP----WKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSV 745

  Fly   415 MSRQR---------------AESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQ 464
            ::||.               :::|....||       .|....|:.:..:.::|        :|.
Mouse   746 LTRQECIERIPWIAPECVEDSKNLSVAADK-------WSFGTTLWEICYNGEIP--------LKD 795

  Fly   465 NARCE---YYLSEKHC------CETIPDL----INYHRHNSGGLACRLKSSPCDRPV-------- 508
            ....|   :|  |..|      |:.:.||    :||              .|..||.
Mouse   796 KTLIEKERFY--ESRCRPVTPSCKELADLMTRCMNY--------------DPNQRPFFRAIMRDI 844

  Fly   509 -------PPTAGLSHDKWEIHPME-----LMLMEELGSGQFGVVRRGKWRGSID-----TAVKMM 556
                   |..........|:.|..     |..:.:||.|.||.|...::....|     .|||.:
Mouse   845 NKLEEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL 909

  Fly   557 K--EGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH--RPIYIVTEYMKHGSLLNYLRRHEKTL 617
            |  .|.....|..:|.:::..|.|.|:|:..|:|.:.  ..|.::.|::..|||..||.:::..:
Mouse   910 KPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKI 974

  Fly   618 IGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ--YTSS 680
              |:...|...||:.|||.||....|:||||||||.||.||:.||:.||||.:.:..|:  ||..
Mouse   975 --NLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVK 1037

  Fly   681 GGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-CG----------KM---PYGRLKNTE 731
            .....|:.|..||.|...:|...||||::||.:.|:.| |.          ||   .:|::..|.
Mouse  1038 DDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTR 1102

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMD 775
            :|..::.|..|..|.:|..|:|.:|:.||...|..|..|:.|::
Mouse  1103 LVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIE 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	41/242 (17%)
		SH3_Tec_like	346..399	CDD:212702	14/72 (19%)
		SH2_Tec_family	403..505	CDD:198188	22/142 (15%)
		PTKc_Tec_like	521..778	CDD:173637	93/285 (33%)
Jak1	NP_666257.2	FERM_F1	<52..129	CDD:465733
		FERM_F2	147..277	CDD:436450
		FERM_C_JAK1	282..426	CDD:275412	30/185 (16%)
		SH2_Jak1	426..526	CDD:198241	22/136 (16%)
		PTK_Jak1_rpt1	582..845	CDD:270662	54/301 (18%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	92/280 (33%)