Protein Alignment Btk29A and Fyn

DIOPT Version :9

• Sequence 1: NP_001097121.1
• Gene: Btk29A / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_030100741.1
• Gene: Fyn / 14360
• MGIID: 95602
• Length: 576
• Species: Mus musculus
• Alignment Length: 564
• Identity: 217/564 - (38%)
• Similarity: 313/564 - (55%)
• Gaps: 45/564 - (7%)

  Fly   242 RSISPNSSTTNSQFSLQH---NSSGSLGGGVGGGLGG----------------GGSLGLGGGGGG 287
            |.|||...:.:.::..:|   .....:||.:|..:.|                .|||....|...
Mouse     5 RGISPGGKSQSDRWFRRHVVYIKFVIVGGNLGAWIMGCVQCKDKEAAKLTEERDGSLNQSSGYRY 69

  Fly   288 GGSCTPTSLQPQSSLTTFKQSPTLLN-----GNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLV 347
            |...||.. .|...:|:.   |...|     |.|    ..:.||:.:.....:........|.|.
Mouse    70 GTDPTPQH-YPSFGVTSI---PNYNNFHAAGGQG----LTVFGGVNSSSHTGTLRTRGGTGVTLF 126

  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWY 411
            ||||.::|....|||..|..::::::.|:..||:.:. ..|..||||||||.|  :..::..|||
Mouse   127 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP--VDSIQAEEWY 189

  Fly   412 VGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHIKQNARCEYYL 472
            .|.:.|:.|| .||..|:..|.|::|:| :|||.|:||:.  ..:...|||||.|::.....||:
Mouse   190 FGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYI 254

  Fly   473 SEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS---HDKWEIHPMELMLMEELGS 534
            :.:...||:..|:.::...:.||.||| ..||.:.:|....||   .|.|||....|.|::.||:
Mouse   255 TTRAQFETLQQLVQHYSERAAGLCCRL-VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGN 318

  Fly   535 GQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTE 599
            ||||.|..|.|.|:...|:|.:|.||||.:.|:|||::|.||:|..|||||.|.|: .|||||||
Mouse   319 GQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTE 382

  Fly   600 YMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVA 664
            ||..||||::|:..|...: .:..|:||..||:.||.|:||.|||||||.:.|.|||:..:.|:|
Mouse   383 YMSKGSLLDFLKDGEGRAL-KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIA 446

  Fly   665 DFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKN 729
            ||||||.:.|::||:..|.||||||..||...|.||:.|||||::|:|:.|:.|.|::||..:.|
Mouse   447 DFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNN 511

  Fly   730 TEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVL 773
            .||:|:|:||..:..|:.|...::::|..||...|||||.|..|
Mouse   512 REVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYL 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	22/53 (42%)
		SH2_Tec_family	403..505	CDD:198188	37/105 (35%)
		PTKc_Tec_like	521..778	CDD:173637	125/253 (49%)
		Pkinase_Tyr	526..777	CDD:285015	124/248 (50%)
Fyn	XP_030100741.1	SH3_Fyn_Yrk	124..179	CDD:212939	22/54 (41%)
		SH2_Src_Fyn_isoform_a_like	184..284	CDD:198281	36/100 (36%)
		PTKc_Fyn	300..573	CDD:270655	128/258 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820