DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Frk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001153016.1	Gene:	Frk / 14302	MGIID:	103265	Length:	512	Species:	Mus musculus

Alignment Length:	467	Identity:	190/467 - (40%)
Similarity:	272/467 - (58%)	Gaps:	25/467 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 PGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWW------KV 382
            ||....|..|.|:..:.|| .:..|||:.::|....|||.....:.:|:|.|.|.||      |.
Mouse    32 PGAFCPPEAPRSQEPERSH-GQYFVALFDYQARTAEDLSFRAGDKLQVLDTSHEGWWLARHLEKK 95

  Fly   383 KDALGN--VGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGL 443
            ...||.  .||||||||.....|..|  .|:.|.:.|..|| .||...::.|.|::|:| |.||.
Mouse    96 GTGLGQQLQGYIPSNYVAEDRSLQAE--PWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGD 158

  Fly   444 YTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDR-P 507
            ::||:   :.:..||||.|::.....::|:.:....|:.:.:||:...|.||..:|: .||.: .
Mouse   159 FSLSV---LDEGVVKHYRIRRLDEGGFFLTRRKVFSTLNEFVNYYTTTSDGLCVKLE-KPCLKIQ 219

  Fly   508 VPPTAGLSH---DKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEE 569
            ||....||:   |:|||....:.|::.|||||||.|..|.|..:...|||.:|.|:|..:||:.|
Mouse   220 VPTPFDLSYKTADQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLRE 284

  Fly   570 AKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKG 634
            |::|..|:||.|:|||.||:...||||:||.|:||||..||:....:.| ::...:||..||:.|
Mouse   285 AQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKI-HLIQQVDMAAQVASG 348

  Fly   635 MTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR-YVLD--DQYTSSGGTKFPIKWAPPEVLN 696
            |.|||..|||||||||||.|||..|:.||||||||| :.:|  |.|.|....|.|:||..||.:.
Mouse   349 MAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIR 413

  Fly   697 YTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWS 761
            ..:||.|||||::|:|::||.|.|||||..:...:|::.:.:...|.:|.:|.::.|.:|..||:
Mouse   414 TNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWN 478

  Fly   762 HGPEERPAFRVL 773
            ..|::||.|..|
Mouse   479 VEPKQRPTFETL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	24/60 (40%)
		SH2_Tec_family	403..505	CDD:198188	32/103 (31%)
		PTKc_Tec_like	521..778	CDD:173637	119/256 (46%)
		Pkinase_Tyr	526..777	CDD:285015	118/251 (47%)
Frk	NP_001153016.1	SH3_Src_like	54..111	CDD:212779	21/56 (38%)
		SH2_Src_Frk	119..214	CDD:199831	30/100 (30%)
		PTKc_Frk_like	232..501	CDD:270653	122/260 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820