Protein Alignment Btk and Fgfr4

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_006517162.3
• Gene: Fgfr4 / 14186
• MGIID: 95525
• Length: 829
• Species: Mus musculus
• Alignment Length: 376
• Identity: 118/376 - (31%)
• Similarity: 186/376 - (49%)
• Gaps: 42/376 - (11%)

  Fly   442 GLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIP------DLINYHRHNSGGLACRLK 500
            |:|    |.:|.:.|.....:.......:.|:.:...|:..      .|:...|.:|.|......
Mouse   415 GVY----HRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTG 475

  Fly   501 SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG--------SIDTAVKMMK 557
            ....|.|:.|.       ||.....|:|.:.||.|.||.|.|.:..|        :...||||:|
Mouse   476 LVNLDLPLDPL-------WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLK 533

  Fly   558 EGTMSED--DFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE----- 614
            :....:|  |.:.|.:||..: :|.|::.|.|||::..|:|::.|....|:|..:||...
Mouse   534 DNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPD 598

  Fly   615 ------KTLIGNMGL--LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARY 671
                  ::..|.:..  |:....||::||.|||....|||||||||.||..::|:|:|||||||.
Mouse   599 LSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARG 663

  Fly   672 VLD-DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVER 735
            |.. |.|..:...:.|:||..||.|....::.:||||::|:|:|||||.|..||..:...|:...
Mouse   664 VHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSL 728

  Fly   736 VQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786
            ::.|..:|:|.:|..|:|.:|:.||...|.:||.|:.|::.|..|...:::
Mouse   729 LREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	11/68 (16%)
		PTKc_Tec_like	521..778	CDD:173637	100/281 (36%)
Fgfr4	XP_006517162.3	IG_like	70..143	CDD:214653
		Ig strand B	80..84	CDD:409353
		Ig strand E	111..115	CDD:409353
		Ig strand F	125..130	CDD:409353
		Ig	174..268	CDD:472250
		Ig strand B	195..199	CDD:409353
		Ig strand C	208..212	CDD:409353
		Ig strand E	234..238	CDD:409353
		Ig strand F	248..253	CDD:409353
		Ig strand G	261..264	CDD:409353
		Ig	276..378	CDD:472250
		Ig strand B	294..298	CDD:409353
		Ig strand C	307..311	CDD:409353
		Ig strand E	343..347	CDD:409353
		Ig strand F	357..362	CDD:409353
		Ig strand G	370..373	CDD:409353
		PTKc_FGFR4	481..794	CDD:133230	106/306 (35%)