DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk and Fgfr3

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001156689.1 Gene:Fgfr3 / 14184 MGIID:95524 Length:802 Species:Mus musculus


Alignment Length:832 Identity:202/832 - (24%)
Similarity:311/832 - (37%) Gaps:238/832 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 ATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLY---- 163
            |.|:|...:|..|:....:.. .|:.....|.|.:...|.|..|.:.....|.|....|::    
Mouse    13 AVVAGATSEPPGPEQRVVRRA-AEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDG 76

  Fly   164 --VIANSE----KERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAH 222
              ::|:..    .:|.:.:.|..   ||:..               :||...|:|     |...|
Mouse    77 TGLVASHRILVGPQRLQVLNASH---EDAGV---------------YSCQHRLTR-----RVLCH 118

  Fly   223 WR-EANNNPSNGSS----------------------------PAQNSTRSISPNSSTTNSQFSLQ 258
            :. ...:.||:|..                            ||.|:.|...|.:.......|..
Mouse   119 FSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL 183

  Fly   259 HNSSGSLGGGVGGGLGGGGSLGLGG-----------------GGGGGGSCTPT----SLQPQSSL 302
            .|           |....|...:||                 ...|..:|...    |::...:|
Mouse   184 KN-----------GKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 237

  Fly   303 TTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNA 367
            ...::||     :..:|.|    |:|...|                      ||.|.|:..    
Mouse   238 DVLERSP-----HRPILQA----GLPANQT----------------------AILGSDVEF---- 267

  Fly   368 EYEVIDDSQEH--WWKVKDALGN-VG-----YIP------SNYVKPKALLGLE------------ 406
            ..:|..|:|.|  |.|..:..|: ||     |:.      |..|:..|.|.|.            
Mouse   268 HCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLC 332

  Fly   407 RYEWYVGDMSR---------QRAESLLKQGDKEG--------------CFV----------VRKS 438
            |...::|...:         |.||..|.:.|:.|              .|:          :|..
Mouse   333 RATNFIGVAEKAFWLRVHGPQAAEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRLRSP 397

  Fly   439 STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSP 503
            ..|||.:.::|      .|..:.:|:....|   |........| |:...|.:||........|.
Mouse   398 PKKGLGSPTVH------KVSRFPLKRQVSLE---SNSSMNSNTP-LVRIARLSSGEGPVLANVSE 452

  Fly   504 CDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG--------SIDTAVKMMKEGT 560
            .:.|..|       |||:....|.|.:.||.|.||.|...:..|        .:..||||:|:..
Mouse   453 LELPADP-------KWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDA 510

  Fly   561 MSED--DFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
            ..:|  |.:.|.::|..: :|.|::.|.|.|::..|:|::.||...|:|..:||.....   .|.
Mouse   511 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPP---GMD 572

  Fly   623 LLLDMC----------------IQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARY 671
            ...|.|                .||::||.||.....|||||||||.||..:||:|:|||||||.
Mouse   573 YSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 637

  Fly   672 VLD-DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVER 735
            |.: |.|..:...:.|:||..||.|....::.:||||::|||:|||||.|..||..:...|:.:.
Mouse   638 VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL 702

  Fly   736 VQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL-ALVAQTLTD 786
            ::.|..::||.||..::|.:|:.||...|.:||.|:.|::.| .::..|.||
Mouse   703 LKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTD 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944 24/128 (19%)
SH3_Tec_like 346..399 CDD:212702 16/66 (24%)
SH2_Tec_family 403..505 CDD:198188 26/146 (18%)
PTKc_Tec_like 521..778 CDD:173637 101/285 (35%)
Fgfr3NP_001156689.1 ig 46..110 CDD:395002 13/81 (16%)
Ig strand B 55..59 CDD:409353 1/3 (33%)
Ig strand C 69..73 CDD:409353 1/3 (33%)
Ig strand E 91..94 CDD:409353 1/2 (50%)
Ig strand F 104..108 CDD:409353 1/18 (6%)
IgI_2_FGFR 145..239 CDD:409443 15/104 (14%)
Ig strand A 145..148 CDD:409443 0/2 (0%)
Ig strand A' 156..161 CDD:409443 0/4 (0%)
Ig strand B 165..173 CDD:409443 2/7 (29%)
Ig strand C 179..184 CDD:409443 1/4 (25%)
Ig strand C' 187..189 CDD:409443 0/1 (0%)
Ig strand D 198..201 CDD:409443 0/2 (0%)
Ig strand E 205..210 CDD:409443 0/4 (0%)
Ig strand F 219..226 CDD:409443 1/6 (17%)
Ig strand G 229..239 CDD:409443 2/9 (22%)
IgI_3_FGFR 247..347 CDD:409363 26/129 (20%)
Ig strand A 247..250 CDD:409363 0/2 (0%)
Ig strand A' 254..258 CDD:409363 1/3 (33%)
Ig strand B 266..273 CDD:409363 1/10 (10%)
Ig strand C 277..284 CDD:409363 2/6 (33%)
Ig strand D 299..304 CDD:409363 1/4 (25%)
Ig strand E 315..320 CDD:409363 2/4 (50%)
Ig strand F 328..336 CDD:409363 1/7 (14%)
Ig strand G 339..347 CDD:409363 1/7 (14%)
PTKc_FGFR3 455..788 CDD:173652 109/310 (35%)

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