DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Fes

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_034324.2 Gene:Fes / 14159 MGIID:95514 Length:822 Species:Mus musculus


Alignment Length:499 Identity:160/499 - (32%)
Similarity:246/499 - (49%) Gaps:68/499 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 CTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKA 355
            |:...||.|..|...|...         |....|..:|.       .:|:.|......     :.
Mouse   372 CSQDKLQAQQELLQSKMEQ---------LGTGEPPAVPL-------LQDDRHSTSSTE-----QE 415

  Fly   356 IEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSR-QR 419
            .|||     :....|::.......::.|.::.     |...:.|:....|....||.|.:.| :.
Mouse   416 REGG-----RTPTLEILKSHFSGIFRPKFSIP-----PPLQLVPEVQKPLYEQLWYHGAIPRAEV 470

  Fly   420 AESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDL 484
            ||.|...||    |:||:|..|..|.||:   :.....:|:.|:.:.  ..|..|.....:||.|
Mouse   471 AELLTHSGD----FLVRESQGKQEYVLSV---MWDGQPRHFIIQSSD--NLYRLEGDGFPSIPLL 526

  Fly   485 INYHRHNSGGLACRLKSSPCDRPVPPTAG------LSHDKWEIHPMELMLMEELGSGQFGVVRRG 543
            |.:           |.||  .:|:...:|      :..|||.:...:|:|.|::|.|.||.|..|
Mouse   527 ITH-----------LLSS--QQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSG 578

  Fly   544 KWRG-SIDTAVKMMKEGTMSED---DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHG 604
            :.|. :...|||..:| |:..|   .|::||:::.:..|||:|:|.|||::.:|||||.|.::.|
Mouse   579 RLRADNTPVAVKSCRE-TLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGG 642

  Fly   605 SLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLA 669
            ..|.:||.....|  .:..||.|....:.||.|||....||||||||||||..:||:|::|||::
Mouse   643 DFLTFLRTEGARL--RVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMS 705

  Fly   670 RYVLDDQYTSSGGTK-FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVV 733
            |...|..|.:|.|.: .|:||..||.|||.|:||:||||::|:|:||.|:.|..||..|.|.:..
Mouse   706 REEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTR 770

  Fly   734 ERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |.|::|..|..|:.|...::.:|:.||::.|.:||:|.::..:|
Mouse   771 EFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQEL 814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 6/52 (12%)
SH2_Tec_family 403..505 CDD:198188 29/102 (28%)
PTKc_Tec_like 521..778 CDD:173637 108/262 (41%)
FesNP_034324.2 Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250 1..300
F-BAR_Fes 7..239 CDD:153369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..420 7/44 (16%)
SH2_Fps_family 453..537 CDD:198224 29/105 (28%)
Protein Kinases, catalytic domain 564..814 CDD:473864 105/252 (42%)
Blue background indicates that the domain is not in the aligned region.

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