DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Ptk2

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_006520478.1 Gene:Ptk2 / 14083 MGIID:95481 Length:1140 Species:Mus musculus


Alignment Length:571 Identity:148/571 - (25%)
Similarity:228/571 - (39%) Gaps:185/571 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   362 SLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNY---VKPKALLGLERYEWYVGDMSRQ----- 418
            :|||.:.|||::         || :|...:.|.:.   ||.|.|..|      :....||     
Mouse   231 ALEKKSNYEVLE---------KD-VGLKRFFPKSLLDSVKAKTLRKL------IQQTFRQFANLN 279

  Fly   419 RAESLLK---------QGDKEGCFVVRKSSTKGLYTLSLHTKV-PQSHVKHYHIKQNARCEYYLS 473
            |.||:||         :.||| ||   |.:....:.:|:...: |:..:.            ||:
Mouse   280 REESILKFFEILSPVYRFDKE-CF---KCALGSSWIISVELAIGPEEGIS------------YLT 328

  Fly   474 EKHCCET---------------------------------------------------------- 480
            :|.|..|                                                          
Mouse   329 DKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCR 393

  Fly   481 -----------------------IPDLINYHRHN--------SGGLACRLKSSP---------CD 505
                                   ||.|.|..:..        ||...|:.|...         |.
Mouse   394 LVNGATQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSGVSHCQHKVKKARRFLPLVFCS 458

  Fly   506 RPVPPTAGLSHDK----------------------------WEIHPMELMLMEELGSGQFGVVRR 542
            ...|||..:|.|:                            :||....:.|...:|.||||.|.:
Mouse   459 LEPPPTDEISGDETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIGEGQFGDVHQ 523

  Fly   543 GKW----RGSIDTAVKMMKEGTMS--EDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYM 601
            |.:    ..::..|:|..|..|..  .:.|::||..|.:..||::|:|.||.::: |::|:.|..
Mouse   524 GVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELC 587

  Fly   602 KHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADF 666
            ..|.|.::|:..:.:|  ::..|:....|:|..:.|||...::|||:||||.||.|.:.||:.||
Mouse   588 TLGELRSFLQVRKYSL--DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDF 650

  Fly   667 GLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTE 731
            ||:||:.|..|..:...|.||||..||.:|:.||:|.||||.:||.||||...|..|:..:||.:
Mouse   651 GLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND 715

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ 782
            |:.|::.|..|..|.:|...:|.:|..||::.|..||.|..|..||:.:.:
Mouse   716 VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 766

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 11/39 (28%)
SH2_Tec_family 403..505 CDD:198188 29/214 (14%)
PTKc_Tec_like 521..778 CDD:173637 97/262 (37%)
Ptk2XP_006520478.1 FERM_N_2 79..174 CDD:436229
B41 80..302 CDD:214604 25/87 (29%)
FERM_C_FAK1 298..408 CDD:270011 13/125 (10%)
PTKc_FAK 500..769 CDD:133187 99/270 (37%)
Focal_AT 1004..1133 CDD:460992
Blue background indicates that the domain is not in the aligned region.

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