DRSC - DRSC Integrative Ortholog Prediction Tool

DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and CRKL

DIOPT Version :10

Sequence 1:	NP_476745.1	Gene:	Btk / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_005198.1	Gene:	CRKL / 1399	HGNCID:	2363	Length:	303	Species:	Homo sapiens

Alignment Length:	11	Identity:	5/11 - (45%)
Similarity:	7/11 - (63%)	Gaps:	0/11 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQNTNMSNMYN 11
            ||:.:..|.||
Human    86 MQDMDEMNDYN 96

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637
CRKL	NP_005198.1	SH2_CRK_like	6..106	CDD:198180	5/11 (45%)
		SH3_CRK_N	126..180	CDD:212692
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..234
		SH3_CRK_C	237..293	CDD:212693
Blue background indicates that the domain is not in the aligned region.

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