DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Csk

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_031809.2 Gene:Csk / 12988 MGIID:88537 Length:450 Species:Mus musculus


Alignment Length:441 Identity:166/441 - (37%)
Similarity:252/441 - (57%) Gaps:26/441 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVIDDSQE-HWWKVKDALGNVGYIPSNYVKP----KALLGLER 407
            :|.|.|......||...|.....::..::: :|:|.|:.:|..|.||:|||:.    ||...|..
Mouse    15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSL 79

  Fly   408 YEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHYHIKQNARCEYY 471
            ..|:.|.::|::||.|| ...:.|.|:||:|:. .|.|||.:..   :..|:||.|..:| .:..
Mouse    80 MPWFHGKITREQAERLL-YPPETGLFLVRESTNYPGDYTLCVSC---EGKVEHYRIMYHA-SKLS 139

  Fly   472 LSEKHCCETIPDLINYHRHNSGGLACRL-KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSG 535
            :.|:...|.:..|:.::..::.||..|| |....:..|..........|.::..||.|::.:|.|
Mouse   140 IDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKG 204

  Fly   536 QFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHR-PIYIVTE 599
            :||.|..|.:||: ..|||.:|....:: .|:.||.|||:|:|.|||||.||..:.: .:|||||
Mouse   205 EFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTE 267

  Fly   600 YMKHGSLLNYLRRHEKTLIGNMGLL---LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVV 661
            ||..|||::|||...::::|...||   ||:|    :.|.|||.:|::||||||||.||..:||.
Mouse   268 YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC----EAMEYLEGNNFVHRDLAARNVLVSEDNVA 328

  Fly   662 KVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGR 726
            ||:||||.:.....|.|.    |.|:||..||.|...:||:|||||::|:|:|||::.|::||.|
Mouse   329 KVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR 389

  Fly   727 LKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            :...:||.||::|..::.|..|...:|:|||.||......||.|..|.:||
Mouse   390 IPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQL 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 16/51 (31%)
SH2_Tec_family 403..505 CDD:198188 30/103 (29%)
PTKc_Tec_like 521..778 CDD:173637 116/261 (44%)
CskNP_031809.2 Interaction with PTPN22. /evidence=ECO:0000269|PubMed:8890164 9..70 16/54 (30%)
SH3_CSK 11..67 CDD:212703 16/51 (31%)
SH2_csk_like 78..175 CDD:198190 29/101 (29%)
PTKc_Csk 188..443 CDD:133213 117/263 (44%)
Blue background indicates that the domain is not in the aligned region.

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