Protein Alignment Btk and LOC1279866

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_061516974.1
• Gene: LOC1279866 / 1279866
• VectorBaseID: AGAMI1_004865
• Length: 1583
• Species: Anopheles gambiae
• Alignment Length: 690
• Identity: 168/690 - (24%)
• Similarity: 255/690 - (36%)
• Gaps: 217/690 - (31%)

  Fly   180 RQVCEDS------NTPKSYRYH---PGLWSGKKWSCCKGLSRTTFG------------------- 216
            |..||.:      ..|..||..   ||||:....:|..|||....|
Mosquito   677 RTSCEGACGLGSLKGPCEYRSQTDLPGLWTEDYPTCSSGLSHCPDGVCDPLEEMGHREKIHICPQ 741

  Fly   217 ----------------------------CRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNS 253
                                        |||:.|....:......|.....:|.|.|..::||.|
Mosquito   742 DCVYKQDIVGLHHSDKARGIQTASGHCSCRASGHCSCIDTLRIPASFKRSKTTTSSSTTTTTTTS 806

  Fly   254 QFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTL 318
            ..:......|:       ..||||.:.:...|...|:......:.:.   ..:.:|.....:|:|
Mosquito   807 TTTTPSYVEGA-------STGGGGEVEVFSVGAKNGTENEAGTRHRD---RSEDAPPAAVRDGSL 861

  Fly   319 LDANMPGGIPTPGTPNSKAKDNSH-------------FVKLVVALYPFKAIEGGDLSLEKNAEYE 370
            .:   ||.|..|           |             .|.:::.||.|        |.:...:.:
Mosquito   862 YE---PGLITGP-----------HASIYLIAIVLIPMVVAVMIVLYCF--------SRKLTVKNK 904

  Fly   371 VIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVV 435
            ::|.|.    .....:|.:..|..|.|                            ..|.| .|.|
Mosquito   905 LLDGSS----GANGTIGGMNSISMNLV----------------------------SNDTE-IFNV 936

  Fly   436 RKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK 500
            .         |.|.|::.:.:.|                          |:|
Mosquito   937 E---------LPLTTRINEINFK--------------------------IDY------------- 953

  Fly   501 SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRG------KWRGSIDTAVKMMKEG 559
                           ..|||.....|:|...||.|:||.|.:|      :..|....||||:|.|
Mosquito   954 ---------------DSKWEFPRTNLILDATLGEGEFGKVLKGFATDLPEKPGITTVAVKMLKTG 1003

  Fly   560 TMSED--DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
            ..|.:  ..:.|.:::.::.|||:::|.|.|:|.....::.||.::|||.||||...|..:.|..
Mosquito  1004 ANSVELLALLSEYQLLQEVNHPNVIRLLGACTKGDTPLLIIEYCQYGSLKNYLRLSRKLEVLNAD 1068

  Fly   623 L-----------LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL-DD 675
            .           :|....|:||||.||.....:||||||||.|:....|.|::||||.|.|. ||
Mosquito  1069 YENAVEPITVKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLTRDVYEDD 1133

  Fly   676 QYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGI 740
            .|......:.|:||..||.|....:::||||||:|||.||:.|.|..||..:....:...:::|.
Mosquito  1134 AYLKKSKDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQNLYNLLKQGY 1198

  Fly   741 ILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALV 780
            .:|.||:|::|||.:::|||:..|::||:|:.|..|..|:
Mosquito  1199 RMECPKNCSEEIYGIVRLCWADDPKQRPSFKHLAGQFELL 1238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	18/97 (19%)
		SH3_Tec_like	346..399	CDD:212702	10/52 (19%)
		SH2_Tec_family	403..505	CDD:198188	10/101 (10%)
		PTKc_Tec_like	521..778	CDD:173637	102/276 (37%)
LOC1279866	XP_061516974.1	None