Protein Alignment Btk and Btk29A

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_061512228.1
• Gene: Btk29A / 1277670
• VectorBaseID: AGAMI1_007842
• Length: 810
• Species: Anopheles gambiae
• Alignment Length: 834
• Identity: 579/834 - (69%)
• Similarity: 633/834 - (75%)
• Gaps: 105/834 - (12%)

  Fly    34 LMSERLYD-VVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGV 97
            :|:||..| |:|||.||||:||||||||||||.||||||:...||:|:.|:|:|||||||.:|||
Mosquito     1 MMTERRSDFVLKSGYMVKRSQNKKRFTPVNYKTRWFELTRFYLSYYDIGNLEKRRERGRISVKGV 65

  Fly    98 RLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTL 162
            ||||.|.:.|||||..|||||||||||||                     .:|...|..:|||||
Mosquito    66 RLVEPALLHGEGGDAAAPDGYPFQVGYCE---------------------SDGIYPGTTLPQYTL 109

  Fly   163 YVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREAN 227
            |::|:|||||:|||.:||:|||: .:|||:.||.|||.|:|||||:.|:|...||:.|..|.|.|
Mosquito   110 YLVADSEKERTEWISSIRKVCEE-YSPKSFSYHLGLWLGRKWSCCRSLNRRALGCQLATIWPEYN 173

  Fly   228 NNPSNGSSPAQNSTRSISPNSSTTN----------------SQFSLQHNS--------------- 261
            ||||.|||||||||||.|||....:                .|..|||:|
Mosquito   174 NNPSTGSSPAQNSTRSTSPNVPNGHLPLPQQQSQVHPQQQPQQQQLQHHSGTVPVLQAHQQQQQQ 238

  Fly   262 ---------------SGSL---------------GGGVGGGL------------GGGGSLGLGGG 284
                           |.||               ...:...|            ....|..|...
Mosquito   239 PQPTQHPPQQHSQSHSPSLQHPAASQQQVHLQQQQAALQAALQQQQPPLLQQQTSQQSSHHLNSS 303

  Fly   285 GGGGGSCTPTSL-QPQS-SLTTFKQSPTLLNGNGTLL----DANMPGG-IPTPGTPNSKAKDNSH 342
            ....|:.|||.: |||| ::.:||.:.  |||.|..:    |.||||| ..||||||:||||.|.
Mosquito   304 SSSLGNITPTFVAQPQSPTVNSFKTAS--LNGVGLHVNGGGDLNMPGGPTVTPGTPNTKAKDVSP 366

  Fly   343 FVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLER 407
            .||:|||||||||||.||||||||||||||||||||||||||..|.:|||||||||.|.||||::
Mosquito   367 RVKIVVALYPFKAIESGDLSLEKNAEYEVIDDSQEHWWKVKDQHGTIGYIPSNYVKEKELLGLQK 431

  Fly   408 YEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYL 472
            |:|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||.|:||
Mosquito   432 YDWYVGDMSRQRAESLLKQNDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARSEFYL 496

  Fly   473 SEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQF 537
            ||||||||||||||||||||||||||||:||||||||||||||||||||||.|||::||||||||
Mosquito   497 SEKHCCETIPDLINYHRHNSGGLACRLKTSPCDRPVPPTAGLSHDKWEIHPSELMILEELGSGQF 561

  Fly   538 GVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMK 602
            |||||.||||||||||||||.||||||||||||||||||||||||||||||||||||||:|||||
Mosquito   562 GVVRRAKWRGSIDTAVKMMKVGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIITEYMK 626

  Fly   603 HGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFG 667
            ||||||||||||::|||||||||||||||.|||:|||||||||||||||||||||||.|||||||
Mosquito   627 HGSLLNYLRRHEQSLIGNMGLLLDMCIQVCKGMSYLERHNYIHRDLAARNCLVGSENTVKVADFG 691

  Fly   668 LARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEV 732
            ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
Mosquito   692 LARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEVFTCGKMPYGRLKNTEV 756

  Fly   733 VERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786
            ||||||||||||||:||||||||||.||||.||:||.||:|.||||.|||.|||
Mosquito   757 VERVQRGIILEKPKACAKEIYDVMKKCWSHSPEDRPGFRILKDQLAAVAQGLTD 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	104/177 (59%)
		SH3_Tec_like	346..399	CDD:212702	46/52 (88%)
		SH2_Tec_family	403..505	CDD:198188	94/101 (93%)
		PTKc_Tec_like	521..778	CDD:173637	237/256 (93%)
Btk29A	XP_061512228.1	None