Protein Alignment Btk and LOC1274321

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_061504086.1
• Gene: LOC1274321 / 1274321
• VectorBaseID: AGAMI1_010576
• Length: 1601
• Species: Anopheles gambiae
• Alignment Length: 744
• Identity: 203/744 - (27%)
• Similarity: 319/744 - (42%)
• Gaps: 162/744 - (21%)

  Fly   131 ANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYH 195
            |...||..|       |.:|.|..|..|.:.....:..|....|         :.:.:|.    |
Mosquito   924 AARQQLSRG-------GPDGHQPERHQPLHPQQAFSEDELLAEE---------QPALSPD----H 968

  Fly   196 PGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSL--- 257
            .|   |.:.:...||. |:|.....|.|||.    .:.::..::|:.:::..|.....:..|
Mosquito   969 SG---GPRATAAGGLG-TSFSQTVRATWREL----IHSTNKVKDSSMNLALRSDRPEEKLDLIAA 1025

  Fly   258 QHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLL--NGNGTLLD 320
            ..:..|.|            |:......||........:......||......||  ....|.|.
Mosquito  1026 DPDRQGLL------------SIRFTFSDGGRKHQLVDGMMASDMHTTADYCVPLLVARSEDTQLQ 1078

  Fly   321 ANMPGGIPTPGTP-----NSKA----KDN--SHFVKLVVALYPFKAIEGGDLS------------ 362
            |..|.|...|.||     .|||    |.|  ....|||..    |...||.:.
Mosquito  1079 AGSPDGDMRPETPVFAQRASKAGPSLKSNLRDKLTKLVHK----KTASGGSVQSGGRSVATAQEV 1139

  Fly   363 --------------------------LEKNAEY---EVIDDSQEHWWKVKDALGNVGY------- 391
                                      |:...|:   ::.:...:|.......:.|:.|
Mosquito  1140 CRTCSKRIVQRSGSDGGGGMHASRTVLDFRKEFPDIDICEGGHDHLDGATSEMINLEYEDIDVLT 1204

  Fly   392 -IPSNYVKPKALLG-------------LERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKG 442
             .|...:.|.|..|             |...||:.|.:.|:....||:   .||.|:||: :|:.
Mosquito  1205 IKPHKLIDPSAAEGGICVSMTLSTNRPLHEEEWFHGVLPREEVVRLLR---NEGDFLVRE-TTRN 1265

  Fly   443 LYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRP 507
            ..:.::.:.....| ||:.::..|. .:|..|.....:|.:|| .|::.|            :.|
Mosquito  1266 DESQTVLSVCWNGH-KHFIVQTTAE-GHYRFEGPAFPSIQELI-VHQYQS------------ELP 1315

  Fly   508 VPPTAG------LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDT--AVKMMKEGTMSED 564
            |...:|      :..::||:...:::|::::|.|.||.|.:.|.:.|.:|  |||..:. |:.|:
Mosquito  1316 VTGRSGAVLRKPVLRERWELSNDDVILLDKIGRGNFGDVYKAKLKSSKNTLVAVKTCRM-TLPEE 1379

  Fly   565 D---FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLD 626
            .   |::|.:::.:..|||:|:|.|:|.:.:||.||.|.:..||||.:||::..||  ....::.
Mosquito  1380 QKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLRKNASTL--GQRQMMG 1442

  Fly   627 MCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTK-FPIKWA 690
            ||...:.||.|||..|.|||||||||||:||||:||::|||::|.  :::|..|||.| .||||.
Mosquito  1443 MCRDAAAGMRYLESKNCIHRDLAARNCLIGSENIVKISDFGMSRE--EEEYIVSGGMKQIPIKWT 1505

  Fly   691 PPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDV 755
            .||.||:.:::|..|||:||:|:||||:.|..||..:.|:...||:..|..:..|:....|:|.:
Mosquito  1506 APEALNFGKYTSLCDVWSYGILVWEIFSRGDTPYSGMSNSMARERIDEGYRMPAPEGAPPEMYRL 1570

  Fly   756 MKLCWSHGPEERPAFRVLMDQLALVAQTL 784
            |..|||:.||.||.|    |::..|...|
Mosquito  1571 MLKCWSYEPESRPHF----DEICSVVDAL 1595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	19/90 (21%)
		SH3_Tec_like	346..399	CDD:212702	11/101 (11%)
		SH2_Tec_family	403..505	CDD:198188	25/114 (22%)
		PTKc_Tec_like	521..778	CDD:173637	109/262 (42%)
LOC1274321	XP_061504086.1	None