DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and Bmx

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_033889.2	Gene:	Bmx / 12169	MGIID:	1101778	Length:	655	Species:	Mus musculus

Alignment Length:	760	Identity:	274/760 - (36%)
Similarity:	395/760 - (51%)	Gaps:	158/760 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 MVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDP 112
            ::|::|.||:.:|.|||.|.|.|||.:.||::.:.::|...:|.|.:|.:|.||:  |:.|...|
Mouse    15 LLKKSQQKKKMSPNNYKERLFVLTKTSLSYYEYDKMKRGSRKGSIEIKKIRCVEK--VNLEEQTP 77

  Fly   113 FAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIR 177
            .... ||||:.|            ::|                     .|||.|::|:.|.:|::
Mouse    78 VERQ-YPFQIVY------------KDG---------------------LLYVYASNEESRCQWLK 108

  Fly   178 AIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTR 242
            |:::... .|.....:||.|.:...|:.||:...:...||.....:.:.:              .
Mouse   109 ALQKEIR-GNPHLLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYADLH--------------I 158

  Fly   243 SISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQ 307
            :||..          :|.:                               ||.  |:..|...:.
Mouse   159 AISDE----------KHRA-------------------------------PTF--PERLLKIPRA 180

  Fly   308 SPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVI 372
            .|.|      .:||:..|.|.......||....|.         |           ..|..|...
Mouse   181 VPVL------KMDASSSGAILPQYDSYSKKSCGSQ---------P-----------TSNIRYIPR 219

  Fly   373 DDSQEHWWKVKDALGNVGYIPSNYVK---------------PKALL-----GLERYEWYVGDMSR 417
            :|..: ||:|:..........||.::               |::..     .|..|:|:.|::||
Mouse   220 EDCPD-WWQVRKLKSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAYDWFAGNISR 283

  Fly   418 QRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIKQNARCEYYLSEKHCCE 479
            .::|.||:|..|||.|:||.||..|:||:||.:|.   .:..|||||:..||..:.||:|.:|.:
Mouse   284 SQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFD 348

  Fly   480 TIPDLINYHRHNSGGLACRLK---SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVR 541
            :||.||:||:|||.|:..||:   |:..:: ||.:..|....||:...|:.|::|||:||||||:
Mouse   349 SIPKLIHYHQHNSAGMITRLRHPVSTKANK-VPVSVALGSGIWELKREEITLLKELGNGQFGVVQ 412

  Fly   542 RGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSL 606
            .|:|:|..|.||||:|||.||||:|.:||:.|.||.||.||:.||||||..||||||||:.:|.|
Mouse   413 LGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCL 477

  Fly   607 LNYLRRHEKTLIGNMGL----LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFG 667
            ||||:.|.|      ||    ||:||..|.:||.:||.|.:||||||||||||.|:..|||:|||
Mouse   478 LNYLKSHGK------GLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFG 536

  Fly   668 LARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEV 732
            :.||||||||.||.|||||:||:.|||.:|.::||||||||:|:||||:|:.||.||....|:||
Mouse   537 MTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEV 601

  Fly   733 VERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |.:|.:|..|.:|:..:..||.:|..||...||:||.|:.|:..:
Mouse   602 VVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAI 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	48/173 (28%)
		SH3_Tec_like	346..399	CDD:212702	9/67 (13%)
		SH2_Tec_family	403..505	CDD:198188	48/112 (43%)
		PTKc_Tec_like	521..778	CDD:173637	147/261 (56%)
		Pkinase_Tyr	526..777	CDD:285015	146/254 (57%)
Bmx	NP_033889.2	PH_Btk	25..151	CDD:269944	44/162 (27%)
		PH	27..115	CDD:278594	35/123 (28%)
		SH2_Tec_Bmx	269..374	CDD:198262	47/104 (45%)
		PKc_like	392..647	CDD:304357	147/261 (56%)
		Pkinase_Tyr	397..646	CDD:285015	146/254 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8183
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm44145
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770