DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Blk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_031575.2	Gene:	Blk / 12143	MGIID:	88169	Length:	499	Species:	Mus musculus

Alignment Length:	453	Identity:	182/453 - (40%)
Similarity:	269/453 - (59%)	Gaps:	16/453 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 PGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDAL-GNVGYIP 393
            |.:||....:...|   ||||:.:.|:...||.:.|..:.:|:..:.: ||..:..: |..||:|
Mouse    43 PPSPNQDPDEEERF---VVALFDYAAVNDRDLQVLKGEKLQVLRSTGD-WWLARSLVTGREGYVP 103

  Fly   394 SNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSH 456
            ||:|.|...|.:|:  |:...:||:.|| .||...:|.|.|::|:| |.||.::||:.....|..
Mouse   104 SNFVAPVETLEVEK--WFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGE 166

  Fly   457 -VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWE 520
             ||||.|:......||:|.:....|:..|:.::.....|| |:..:.||....|... .:.|:||
Mouse   167 VVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSKKGDGL-CQKLTLPCVNLAPKNL-WAQDEWE 229

  Fly   521 IHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLY 585
            |....|.|:.:|||||||.|..|.::.::..|:|.:||||||.:.|:.||.||..|||..||:||
Mouse   230 IPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLY 294

  Fly   586 GVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAA 650
            .|.:: .|||||||||..|.||::|:..|.:.: ::..|:||..||::||.|:||.|.|||||.|
Mouse   295 AVVTR-EPIYIVTEYMARGCLLDFLKTDEGSRL-SLPRLIDMSAQVAEGMAYIERMNSIHRDLRA 357

  Fly   651 RNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWE 715
            .|.||......|:||||||| ::|.:||:..|.||||||..||.:::..|:.|:|||::|||:.|
Mouse   358 ANILVSETLCCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLME 421

  Fly   716 IFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIY-DVMKLCWSHGPEERPAFRVLMDQL 777
            |.|.|::||..:.|.||:..::.|..:..|::|..|:| |::..||...|||||.|..|...|
Mouse   422 IVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/53 (34%)
		SH2_Tec_family	403..505	CDD:198188	34/104 (33%)
		PTKc_Tec_like	521..778	CDD:173637	120/258 (47%)
		Pkinase_Tyr	526..777	CDD:285015	118/251 (47%)
Blk	NP_031575.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		SH3	56..109	CDD:302595	19/56 (34%)
		SH2_Src_Blk	114..213	CDD:198234	32/101 (32%)
		PKc_like	227..490	CDD:304357	122/261 (47%)
		Pkinase_Tyr	235..484	CDD:285015	118/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820