DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Abl2

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_033725.2	Gene:	Abl2 / 11352	MGIID:	87860	Length:	1182	Species:	Mus musculus

Alignment Length:	554	Identity:	211/554 - (38%)
Similarity:	298/554 - (53%)	Gaps:	61/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 GSSPAQNSTRSISPNSSTTNSQFSL--QHNSSGS-LGGGVGGGLGGGGSLGLGGGGGGGGSCTPT 294
            |||.|:.|.|...|...|.::.|::  ||:...| :..|..|...||.|              |.
Mouse    24 GSSAARPSGRRRDPAGRTADAGFNVFTQHDHFASCVEDGFEGDKTGGSS--------------PE 74

  Fly   295 SLQPQSSLTTFKQSPTLLN------GNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPF 353
            .|..........|:   ||      ....||.|       |...||           |.||||.|
Mouse    75 VLHRPFGCDAESQA---LNEAIRWSSKENLLGA-------TESDPN-----------LFVALYDF 118

  Fly   354 KAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQ 418
            .|.....||:.|..:..|:..:|...|....:....|::||||:.|  :..||::.||.|.:||.
Mouse   119 VASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITP--VNSLEKHSWYHGPVSRS 181

  Fly   419 RAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIP 482
            .||.|| .....|.|:||:| |:.|..::||..   :..|.||.|......:.|::.:....|:.
Mouse   182 AAEYLL-SSLINGSFLVRESESSPGQLSISLRY---EGRVYHYRINTTTDSKVYVTAESRFSTLA 242

  Fly   483 DLINYHRHNSGGLACRL--KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKW 545
            :|:::|...:.||...|  .:..|::|........|||||:...::.:..:||.||:|.|..|.|
Mouse   243 ELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 307

  Fly   546 RG-SIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNY 609
            :. |:..|||.:||.||..::|::||.||.:::|||||||.|||:...|.|||||||.:|:||:|
Mouse   308 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 372

  Fly   610 LR---RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARY 671
            ||   |.|.|.:    :||.|..|:|..|.|||:.|:|||||||||||||..:|||||||||:|.
Mouse   373 LRECSREEVTAV----VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 433

  Fly   672 VLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERV 736
            :..|.||:..|.||||||..||.|.|..||.||||||:|||:|||.|.|..||..:..::|.:.:
Mouse   434 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLL 498

  Fly   737 QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            ::|..:|:|:.|..::|::|:.||...|.:||:|
Mouse   499 EKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/52 (35%)
		SH2_Tec_family	403..505	CDD:198188	31/104 (30%)
		PTKc_Tec_like	521..778	CDD:173637	126/254 (50%)
		Pkinase_Tyr	526..777	CDD:285015	126/249 (51%)
Abl2	NP_033725.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		7/17 (41%)
		CAP	2..106		25/105 (24%)
		SH3_Abl	111..164	CDD:212784	18/52 (35%)
		SH2_ABL	169..262	CDD:198189	30/96 (31%)
		PTKc_Abl	281..543	CDD:270645	128/256 (50%)
		STYKc	288..539	CDD:214568	126/249 (51%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		13/23 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..642
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..674
		Nuclear localization signal. /evidence=ECO:0000255	659..661
		F-actin-binding	695..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1059
		F-actin-binding	1020..1182
		FABD	1063..1182	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910