DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Abl1

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001106174.1	Gene:	Abl1 / 11350	MGIID:	87859	Length:	1142	Species:	Mus musculus

Alignment Length:	505	Identity:	193/505 - (38%)
Similarity:	280/505 - (55%)	Gaps:	55/505 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 GGGSC------------TPTSLQPQ--SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKA 337
            ||..|            ..:..:||  |....:.....||.|             |:...||
Mouse    35 GGPHCNVFVEHEALQRPVASDFEPQGLSEAARWNSKENLLAG-------------PSENDPN--- 83

  Fly   338 KDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKAL 402
                    |.||||.|.|.....||:.|..:..|:..:....|.........|::||||:.|  :
Mouse    84 --------LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITP--V 138

  Fly   403 LGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNA 466
            ..||::.||.|.:||..||.||..| ..|.|:||:| |:.|..::||..   :..|.||.|...:
Mouse   139 NSLEKHSWYHGPVSRNAAEYLLSSG-INGSFLVRESESSPGQRSISLRY---EGRVYHYRINTAS 199

  Fly   467 RCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS--HDKWEIHPMELMLM 529
            ..:.|:|.:....|:.:|:::|...:.||...|......|..|...|:|  :||||:...::.:.
Mouse   200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMK 264

  Fly   530 EELGSGQFGVVRRGKWRG-SIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRP 593
            .:||.||:|.|..|.|:. |:..|||.:||.||..::|::||.||.:::|||||||.|||::..|
Mouse   265 HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP 329

  Fly   594 IYIVTEYMKHGSLLNYLR---RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLV 655
            .||:||:|.:|:||:|||   |.|.:.:    :||.|..|:|..|.|||:.|:||||||||||||
Mouse   330 FYIITEFMTYGNLLDYLRECNRQEVSAV----VLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 390

  Fly   656 GSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCG 720
            |..::||||||||:|.:..|.||:..|.||||||..||.|.|.:||.||||||:|||:|||.|.|
Mouse   391 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 455

  Fly   721 KMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAF 770
            ..||..:..::|.|.:::...:|:|:.|.:::|::|:.||...|.:||:|
Mouse   456 MSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/52 (33%)
		SH2_Tec_family	403..505	CDD:198188	33/102 (32%)
		PTKc_Tec_like	521..778	CDD:173637	122/254 (48%)
		Pkinase_Tyr	526..777	CDD:285015	122/249 (49%)
Abl1	NP_001106174.1	SH3_Abl	84..137	CDD:212784	17/52 (33%)
		SH2_ABL	142..235	CDD:198189	32/96 (33%)
		PTKc_Abl	254..516	CDD:270645	124/256 (48%)
		Pkinase_Tyr	261..512	CDD:285015	122/249 (49%)
		FABD	1018..1142	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910