Protein Alignment Btk and MERTK

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_006334.2
• Gene: MERTK / 10461
• HGNCID: 7027
• Length: 999
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 113/334 - (33%)
• Similarity: 173/334 - (51%)
• Gaps: 37/334 - (11%)

  Fly   471 YLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSG 535
            |:::|..|....:|..:....|..|..:|:....||.:                 |:|.:.||.|
Human   549 YIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNL-----------------LILGKILGEG 596

  Fly   536 QFGVVRRGKWR----GSIDTAVKMMKEGTMSE---DDFIEEAKVMTKLQHPNLVQLYGVCSK--- 590
            :||.|..|..:    .|:..|||.||....|:   ::|:.||..|....|||:::|.|||.:
Human   597 EFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSS 661

  Fly   591 ---HRPIYIVTEYMKHGSLLNYLRRHEKTLIG----NMGLLLDMCIQVSKGMTYLERHNYIHRDL 648
               .:|: ::..:||:|.|..|| .:.:...|    .:..||...:.::.||.||...|::||||
Human   662 QGIPKPM-VILPFMKYGDLHTYL-LYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDL 724

  Fly   649 AARNCLVGSENVVKVADFGLARYVLDDQYTSSGG-TKFPIKWAPPEVLNYTRFSSKSDVWAYGVL 712
            |||||::..:..|.||||||::.:....|...|. .|.|:||...|.|....::|||||||:||.
Human   725 AARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVT 789

  Fly   713 MWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ||||.|.|..||..::|.|:.:.:..|..|::|:.|..|:|::|..||...|.:||.|.||..||
Human   790 MWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQL 854

  Fly   778 ALVAQTLTD 786
            ..:.::|.|
Human   855 EKLLESLPD 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	7/33 (21%)
		PTKc_Tec_like	521..778	CDD:173637	101/274 (37%)
MERTK	NP_006334.2	Ig	111..176	CDD:409353
		Ig strand B	111..115	CDD:409353
		Ig strand C	127..131	CDD:409353
		Ig strand E	158..162	CDD:409353
		Ig strand F	172..176	CDD:409353
		IgI_2_Axl_Tyro3_like	198..279	CDD:409407
		Ig strand A	198..201	CDD:409407
		Ig strand A'	204..208	CDD:409407
		Ig strand B	212..221	CDD:409407
		Ig strand C	226..233	CDD:409407
		Ig strand C'	235..238	CDD:409407
		Ig strand E	243..254	CDD:409407
		Ig strand F	257..266	CDD:409407
		Ig strand G	270..279	CDD:409407
		FN3	284..378	CDD:238020
		FN3	386..478	CDD:238020
		PTKc_Mer	579..862	CDD:271106	104/301 (35%)