Protein Alignment Btk and LOC101733045

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_031757813.1
• Gene: LOC101733045 / 101733045
• XenbaseID: XB-GENE-29086679
• Length: 568
• Species: Xenopus tropicalis
• Alignment Length: 549
• Identity: 184/549 - (33%)
• Similarity: 270/549 - (49%)
• Gaps: 56/549 - (10%)

  Fly   260 NSSGSLGGGVGGGLGG----------GGSLGLGGGGGGGGSCTPTSLQPQSSL-TTFKQSPTLLN 313
            |...||.|..|.|.|.          .|:.|.|....|.|...| ...||..| ...:..|.|::
 Frog    37 NLPPSLPGTRGKGQGTPQVTRYKMHLTGTSGQGWAPSGQGKENP-GFVPQDELDNPMRMEPQLIH 100

  Fly   314 GNGTLLDANMPGGIPTPGTPN---SKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDS 375
                      ....|:|..|:   ...|..|...|  |::|.:.|...|.:.:::....||| .:
 Frog   101 ----------EPQHPSPEQPSVGVLHPKQLSRAAK--VSMYSYTARSPGGMDVQRGDRLEVI-GT 152

  Fly   376 QEHWWKVKDALG----NVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAES-LLKQGDKEGCFVV 435
            :..|..|:...|    ...|||.:::....  .||..:||.|.:.|..|:. ||::.:..|.|:|
 Frog   153 KGPWVLVQRETGRGPAQTCYIPKSFLADAG--SLEAEDWYFGGIRRMDAKRFLLQEPNGSGSFLV 215

  Fly   436 RKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK 500
            ..|...  |.||:  :|.|: |:||.|.| |:..|||.|:....|:..|:.|::..|.||..||
 Frog   216 WHSDAS--YWLSV--RVEQT-VRHYRITQ-AQGAYYLVERAAFRTLGALVLYYQQQSDGLCTRL- 273

  Fly   501 SSPC---DRPVPPTAGLSH---DKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEG 559
            ..||   |  ||....|.|   |:.||.|..:..:.:||.|.||:|..|||.|:...|:|.::..
 Frog   274 GKPCVWLD--VPRMPSLCHTAVDQLEISPNSIERIRKLGRGSFGLVWLGKWNGTTQVAIKELQVT 336

  Fly   560 TMS-EDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGL 623
            ..| :.....||..|.||.|..|::||.||.:..|::||||||:.|:|..|||.|::.....:..
 Frog   337 AQSLQKSLYGEADTMWKLSHERLLKLYAVCLQVSPVFIVTEYMERGTLKRYLRDHQQNRNLELQQ 401

  Fly   624 LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIK 688
            |:|...|:.:||.|:|::..:||||.|.|.|:.:....|:.||||||::.......|...:.|||
 Frog   402 LMDFAAQICQGMGYMEQNLCVHRDLRAENILLSAMLSCKIGDFGLARFMDSSSIAMSADARIPIK 466

  Fly   689 WAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVV-ERVQRGIILEKPKSCAKEI 752
            |..|||.:..|:|||||||::|||:.||.|.||||:..:.|.:.| |.::.|..|:.|:.....:
 Frog   467 WMAPEVFSEQRYSSKSDVWSFGVLLVEIVTYGKMPFPEITNEQYVREMLREGGTLQPPRDAPDNV 531

  Fly   753 YDVMKLCWSHGPEERPAF----RVLMDQL 777
            ..:|.:||......||.|    |::||.|
 Frog   532 SYIMNMCWRRAAPTRPTFAELERLIMDLL 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	13/56 (23%)
		SH2_Tec_family	403..505	CDD:198188	38/105 (36%)
		PTKc_Tec_like	521..778	CDD:173637	102/263 (39%)
LOC101733045	XP_031757813.1	SH2	185..276	CDD:472789	35/97 (36%)
		STYKc	303..556	CDD:214568	97/252 (38%)