DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and tyk2

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_003198201.2 Gene:tyk2 / 100536675 ZFINID:ZDB-GENE-071116-4 Length:1165 Species:Danio rerio


Alignment Length:334 Identity:92/334 - (27%)
Similarity:153/334 - (45%) Gaps:78/334 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 CETIPD---LINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGV 539
            ||::||   .:.|.|:                                   |..:.:||.|.||.
Zfish   855 CESLPDKDPSVFYKRY-----------------------------------LRKIRDLGEGHFGK 884

  Fly   540 VR----------RGKWRGSIDTAVKMMK---EGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSK- 590
            |.          .|::     .|||.:|   :|:.....:::|.:::..|.|.|:|:..|.|:: 
Zfish   885 VMLYVYDPHNDGTGEY-----VAVKALKQEGDGSSLHVSWMKEIEILKSLYHNNIVKYKGCCTEM 944

  Fly   591 -HRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCL 654
             .:.:.::.||:..|||..|:.::.:.:  ..|||...  |:..||.||....||||||||||.|
Zfish   945 GGQVVQLIMEYVPLGSLREYMPKYGQGI--GQGLLFAQ--QICLGMDYLHSKRYIHRDLAARNVL 1005

  Fly   655 VGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF 717
            :.:|.|||:.||||.:|:.  |..|........|:.|...|.|..::||..||||::.|.::||.
Zfish  1006 LENEGVVKIGDFGLTKYIPEGDIYYRVREDGDSPVFWYAIECLKESKFSFASDVWSFAVTLYEIL 1070

  Fly   718 T-CGK-------------MPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERP 768
            | |..             ..:|::...:::..:::...|..|..|.:|:|.:|:.||...|::||
Zfish  1071 TNCSHRLSPPSKFSDMMGTVHGQMTVVKLISLLEKNERLPCPPGCPREVYSLMEQCWDFNPDQRP 1135

  Fly   769 AFRVLMDQL 777
            :|..|.:.|
Zfish  1136 SFLSLAESL 1144

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 6/29 (21%)
PTKc_Tec_like 521..778 CDD:173637 86/288 (30%)
tyk2XP_003198201.2 FERM_F1 26..121 CDD:465733
FERM_F2 134..264 CDD:436450
FERM_C_TYK2 268..414 CDD:275414
SH2 414..511 CDD:472789
Protein Kinases, catalytic domain 571..842 CDD:473864
Protein Kinases, catalytic domain 866..1147 CDD:473864 88/323 (27%)
Blue background indicates that the domain is not in the aligned region.

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