DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and blk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_031758933.1	Gene:	blk / 100496460	XenbaseID:	XB-GENE-13579897	Length:	440	Species:	Xenopus tropicalis

Alignment Length:	437	Identity:	179/437 - (40%)
Similarity:	253/437 - (57%)	Gaps:	21/437 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 LYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVG 413
            :|.:..|..|||.|.|..:.:::...:..||..:. ..|..||||||||.|......|.:  :..
Frog     1 MYDYAPINSGDLQLHKGEKLQLLSKDKGEWWLARSLTSGQEGYIPSNYVSPANNADAELF--FFK 63

  Fly   414 DMSRQRAE-SLLKQGDKEGCFVVRKSST-KGLYTLSLHTK--VPQSHVKHYHIKQNARCEYYLSE 474
            .:||:.|| .||..|:|.|.|::|.|.| :|.::||:..:  .....:|||.|:......:|:|.
Frog    64 SISRKDAERQLLAPGNKPGTFLIRDSETSQGTFSLSVRDRDLATGDVIKHYKIRTLDSGGFYISP 128

  Fly   475 KHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGV 539
            .....::.||:.|:...|.|| |:....||...||  .....|.|||....|.|::.||:||||.
Frog   129 ALTFCSLQDLVKYYSKKSDGL-CQKLGQPCPHQVP--NNWQADVWEIPRDSLKLVKRLGAGQFGE 190

  Fly   540 VRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHG 604
            |..|.::.::..|:|.:||||||.:.|:|||.:|..|||..||||:.|.:| .|||||||||.:|
Frog   191 VWMGYYKNNMKVAIKTLKEGTMSREAFLEEANLMKTLQHDKLVQLFAVVTK-EPIYIVTEYMANG 254

  Fly   605 SLLNYLRRHEKTLIGNMGL----LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVAD 665
            |||::|:..|     .|.|    |:||..||::||.|:|:.|||||||.|.|.||......|:.|
Frog   255 SLLDFLKTSE-----GMNLTFSKLVDMSAQVAEGMAYIEKKNYIHRDLRAANVLVSEILCCKIGD 314

  Fly   666 FGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNT 730
            ||||| |:|.:||:..|:||||||..||.:|:..|:.|||||::|:|:.||.|.|:.||..:.|.
Frog   315 FGLAR-VIDTEYTAKEGSKFPIKWTAPEAINFGIFTIKSDVWSFGILLTEIATFGRSPYPGMTNP 378

  Fly   731 EVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            ||:..:.:|..:.:|..|..|:|::|..||....||||.|..|...|
Frog   379 EVICNLDQGYRMPRPNDCPMELYEIMLRCWRDNAEERPTFDYLQSVL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/49 (37%)
		SH2_Tec_family	403..505	CDD:198188	31/105 (30%)
		PTKc_Tec_like	521..778	CDD:173637	123/261 (47%)
		Pkinase_Tyr	526..777	CDD:285015	121/254 (48%)
blk	XP_031758933.1	SH3	1..51	CDD:418401	18/49 (37%)
		SH2_Src_family	56..156	CDD:199827	30/102 (29%)
		PKc_like	170..431	CDD:419665	125/263 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010