DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and map3k13

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_002936577.1	Gene:	map3k13 / 100493878	XenbaseID:	XB-GENE-5753317	Length:	963	Species:	Xenopus tropicalis

Alignment Length:	310	Identity:	104/310 - (33%)
Similarity:	157/310 - (50%)	Gaps:	29/310 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 INYHRHNSGGLACRLKSSPCDRPVPPTAGLSH---------DKWEIHPMELMLMEELGSGQFGVV 540
            |::.|..||..........|.|||....|.::         |.||:...|:..::.||||..|.|
Frog   119 IHFSRSGSGNGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAV 183

  Fly   541 RRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIY-IVTEYMKHG 604
            ..||:||. :.|:|.::|  ..|.|.    |.:.||:|||::...|||:: .|.| ::.||..||
Frog   184 FLGKFRGE-EVAIKKVRE--QKETDI----KHLRKLKHPNIIAFKGVCTQ-APCYCLIMEYCAHG 240

  Fly   605 SLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLA 669
            .|...||...|.   ...||:|....::.||.||..|..|||||.:.|.||...:.||::|||.:
Frog   241 QLYEVLRAGRKV---TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHADTVKISDFGTS 302

  Fly   670 RYVLDDQYT--SSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEV 732
            : .|.|:.|  |..||   :.|..|||:.....|.|.|:|::|||:||:.| |::||..:.::.:
Frog   303 K-ELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVLLWELLT-GEIPYKDVDSSAI 362

  Fly   733 VERV-QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVA 781
            :..| ...:.|..|.:|......:||..|...|..||:||.::..|.:.:
Frog   363 IWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQILMHLDIAS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	4/19 (21%)
		PTKc_Tec_like	521..778	CDD:173637	91/260 (35%)
		Pkinase_Tyr	526..777	CDD:285015	90/254 (35%)
map3k13	XP_002936577.1	STKc_MAP3K12_13	175..411	CDD:270961	91/251 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910