DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and fgr

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_002934688.1	Gene:	fgr / 100493811	XenbaseID:	XB-GENE-6073541	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	200/533 - (37%)
Similarity:	298/533 - (55%)	Gaps:	65/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 TTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNG 314
            |:...|.:|...:..:..|:||.:.|....|:|.|..||             :|.|
Frog    30 TSQMPFRIQETHTPFISAGIGGVIAGSSQRGMGVGVTGG-------------VTQF--------- 72

  Fly   315 NGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHW 379
                                             :|||.:.|....||:.:|..::.:|::|:..|
Frog    73 ---------------------------------IALYDYDARTEDDLTFKKGEKFHIINNSEGDW 104

  Fly   380 WKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLK-QGDKEGCFVVRKS-STK 441
            |:.:. :.||.||||||||.|  :..::..:||.|.:.|:.||.||. :|:..|.|::|:| :||
Frog   105 WEARSLSSGNTGYIPSNYVAP--MNSIQSKDWYFGKIGRKDAERLLLCEGNPRGTFMIRESETTK 167

  Fly   442 GLYTLSLH--TKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC 504
            |.|:||:.  ......|.|||.|::.....:|::.:...:|:.:|:.::...:.|| |.|.::||
Frog   168 GAYSLSVRDWDATRGDHAKHYKIRKLDNGGFYITTRVQFDTVEELVEHYSEFNDGL-CHLLTNPC 231

  Fly   505 DRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEE 569
            ....|.|.|||.|.|||....:.|.::||.|.||.|.:|.|.|:.:.|||.:|..|||.:.|:||
Frog   232 INQKPQTLGLSKDAWEITRDSISLDKKLGQGCFGDVWKGTWNGTTNVAVKTLKPSTMSPEAFLEE 296

  Fly   570 AKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKG 634
            |::|.||:|..|||||.|.|: .|||||||:|..||||:||:..|..|: .:..|:||..|::.|
Frog   297 AQIMKKLRHDKLVQLYAVVSE-EPIYIVTEFMTKGSLLDYLKEGEGHLL-KLPQLVDMSGQIASG 359

  Fly   635 MTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTR 699
            |.|:||.|||||||.|.|.|||...:.|:|||||||.:.|::||:..|.||||||..||...|.:
Frog   360 MAYIERMNYIHRDLRAANILVGDNLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGK 424

  Fly   700 FSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGP 764
            |:.|||||::|:::.|:.|.|::||..:.|.||:|:|:||..:..|.:|...::::|..||...|
Frog   425 FTIKSDVWSFGIMVCELVTKGRIPYPGMSNREVLEQVERGYRMPAPPACPPSLHELMLQCWRGDP 489

  Fly   765 EERPAFRVLMDQL 777
            ||||.|..|...|
Frog   490 EERPTFEYLQSFL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	21/53 (40%)
		SH2_Tec_family	403..505	CDD:198188	32/105 (30%)
		PTKc_Tec_like	521..778	CDD:173637	123/257 (48%)
		Pkinase_Tyr	526..777	CDD:285015	121/250 (48%)
fgr	XP_002934688.1	SH3	72..125	CDD:388381	22/94 (23%)
		SH2_Src_Fgr	130..230	CDD:198230	31/100 (31%)
		PTKc_Src_Fyn_like	257..504	CDD:271105	121/248 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010