DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and itk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_031754542.1	Gene:	itk / 100492561	XenbaseID:	XB-GENE-957720	Length:	616	Species:	Xenopus tropicalis

Alignment Length:	751	Identity:	282/751 - (37%)
Similarity:	390/751 - (51%)	Gaps:	152/751 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVS 106
            |:....::|::|.|:|.:|.|||.|.|.||..:.:|::....:.|..||.|.|..::.||..|..
Frog     5 VILQQQLIKKSQQKRRTSPANYKSRIFILTHSSLNYYEHRQGKIRALRGSIDLARIKCVEIVTTD 69

  Fly   107 GEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKE 171
            ....   ..:.|||||                                  :..|.|||.|...:.
Frog    70 LSIA---CRNKYPFQV----------------------------------IHDYFLYVFAPDRES 97

  Fly   172 RSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSP 236
            |.:|:.|:::..:|::...: :||...|...:|.||....:...||
Frog    98 RQKWVLALKEETKDNDFLVA-KYHSNFWLEGRWRCCFQTEKMATGC------------------- 142

  Fly   237 AQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSS 301
                                                                      :|..:|.
Frog   143 ----------------------------------------------------------ALYDRSK 149

  Fly   302 LTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVK---LVVALYPFKAIEGGDLSL 363
            ..:.|                     |.|.|||    ||..|..   ..||||.:||....:|:|
Frog   150 DVSKK---------------------PLPPTPN----DNMVFQANQGWEVALYDYKAQSSQELTL 189

  Fly   364 EKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGD 428
            .:..||..:|.|:.|||||.|..|:||::||:|:..|....|..|:||..::||..|..||....
Frog   190 CRGEEYLPLDTSEPHWWKVLDKNGHVGHVPSSYLAKKTEDSLLAYKWYNKNVSRNLAVKLLTDQG 254

  Fly   429 KEGCFVVRKSSTKGLYTLSLHTKV--PQSH-VKHYHIK--QNARCEYYLSEKHCCETIPDLINYH 488
            |||.|:||.|...||||:|:.||.  ..:| ||||||:  .::..:|||:|||...:||:|||||
Frog   255 KEGAFMVRDSRQPGLYTVSIFTKALGENNHAVKHYHIRHTNDSPAKYYLAEKHVFNSIPELINYH 319

  Fly   489 RHNSGGLACRLKSSPCD--RPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDT 551
            :||..||..||:...|.  ...|.|||||:.||||.|..|.|.||:||||||||:...|:|:...
Frog   320 QHNGAGLVTRLRYPVCSWKETAPVTAGLSYGKWEIDPTHLTLKEEIGSGQFGVVQLAIWQGTTKV 384

  Fly   552 AVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKT 616
            ||||::||.|||:||:|||:|:.||.||.||||.|||::..||::|.||||:|.|.||||.|..|
Frog   385 AVKMIREGMMSEEDFVEEAQVLMKLSHPKLVQLLGVCTQQVPIFLVFEYMKYGCLFNYLRSHRGT 449

  Fly   617 LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSG 681
            |  :....|.||..|.:||.||||.|:|||||||||||||...||||:|||:.|:|||||||||.
Frog   450 L--SKETALGMCQDVCEGMQYLERSNFIHRDLAARNCLVGESLVVKVSDFGMTRFVLDDQYTSSS 512

  Fly   682 GTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPK 746
            |||||:||:.|||..:..:||:||||::|||:||:|:.||:|:..|.|:|.||::..|:.|.|||
Frog   513 GTKFPVKWSAPEVFRFGLYSSRSDVWSFGVLVWEVFSEGKIPFEHLSNSEAVEKISAGLRLFKPK 577

  Fly   747 SCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ 782
            ..::.:|.:|..||....:.||.|:.|:.::..:|:
Frog   578 MSSERVYKLMNNCWQEKADLRPTFQQLLKEVMDIAE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	43/177 (24%)
		SH3_Tec_like	346..399	CDD:212702	24/52 (46%)
		SH2_Tec_family	403..505	CDD:198188	49/106 (46%)
		PTKc_Tec_like	521..778	CDD:173637	142/256 (55%)
		Pkinase_Tyr	526..777	CDD:285015	140/250 (56%)
itk	XP_031754542.1	PH_Btk	7..146	CDD:269944	44/253 (17%)
		SH3	174..226	CDD:418401	24/51 (47%)
		SH2_Tec_Itk	229..336	CDD:198259	49/106 (46%)
		PKc_like	354..608	CDD:419665	142/255 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1217
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	580	1.000	Inparanoid score	I1012
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm49323
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050