DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and tec

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_031751261.1	Gene:	tec / 100491653	XenbaseID:	XB-GENE-6076361	Length:	648	Species:	Xenopus tropicalis

Alignment Length:	773	Identity:	312/773 - (40%)
Similarity:	423/773 - (54%)	Gaps:	156/773 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KSFQAKMDLMSERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERG 90
            |:.:.::::.|    |::...|::||:|.|||.:|:|||.|.|.|||...:|:: ...|::.::|
Frog    13 KTNEQRVEMNS----DIILEESLIKRSQQKKRTSPLNYKERVFVLTKSRLTYYE-GRPEKKNKKG 72

  Fly    91 RIHLKGVRLVEEATVSGEGGDPFAPDG---------YPFQVGYCEISASANSHQLENGNGGGSGV 146
            .:.:..|:.||           |..:|         |.||:.|     .:|
Frog    73 SVDITKVKCVE-----------FVKNGSENIPCQYKYAFQIVY-----ESN-------------- 107

  Fly   147 GIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLS 211
                          ||||.|.:.:.|.:|::.|::..::::...| :|||..|:...:.||:...
Frog   108 --------------TLYVFAPTAESRFKWVKLIKEEVKNNSFIMS-KYHPQFWADGVYQCCRQTE 157

  Fly   212 RTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGG 276
            :...||.                                       ::|..|.:
Frog   158 KLAPGCE---------------------------------------EYNLFGDI----------- 172

  Fly   277 GSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNS 341
                           |...|.|         :|..:....           |.|..|:.:.:||.
Frog   173 ---------------TKKPLPP---------TPDAIRARP-----------PPPRPPDPEPEDNG 202

  Fly   342 HFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLE 406
            .  :.|:|::.|..:|..||.|....||.|::....||||.::..|..||||||||..|.|..|.
Frog   203 E--ETVIAMFDFHPVEPHDLRLVTGEEYFVLEKKDAHWWKARNTYGQQGYIPSNYVTEKKLDNLY 265

  Fly   407 RYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIKQNA-R 467
            :||||..:|:|.:||.|||..||||.|:||.||..||||:||:||.   ..:.::|||||:.. .
Frog   266 QYEWYSRNMNRSKAEQLLKSEDKEGGFIVRNSSQAGLYTVSLYTKYGGEGSTCIRHYHIKETQYP 330

  Fly   468 CEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC--DRPVPPTAGLSHDKWEIHPMELMLME 530
            .:|||:|||...|||::|.||:||:.||..||:...|  ::..|.|||.|:|||||:|.||..|:
Frog   331 KKYYLAEKHVFNTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSYDKWEINPSELTFMK 395

  Fly   531 ELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIY 595
            |||||.|||||.||||.....|:|.::||.|||:|||||||||.||.|..||||||||::.||||
Frog   396 ELGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHLKLVQLYGVCTQQRPIY 460

  Fly   596 IVTEYMKHGSLLNYLR-RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN 659
            ||||:|:||.|||||| ||.:.   :..:||.||..|.:.|:|||::|:||||||||||||....
Frog   461 IVTEFMEHGCLLNYLRQRHGQF---SPDILLSMCQDVCEAMSYLEQNNFIHRDLAARNCLVNDAG 522

  Fly   660 VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPY 724
            ||||:|||:.|||||||||||.|.|||:||:||||.||:|||||||||::||||||:||.||||:
Frog   523 VVKVSDFGMTRYVLDDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGKMPF 587

  Fly   725 GRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQ 782
            ....|.||||.|.||..|.:||...|.||.||..||...||.||.|..||.|:.|:.:
Frog   588 ESYSNVEVVEMVTRGERLYRPKLATKIIYSVMVACWHEKPEGRPKFFDLMKQIGLILE 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	46/186 (25%)
		SH3_Tec_like	346..399	CDD:212702	23/52 (44%)
		SH2_Tec_family	403..505	CDD:198188	53/107 (50%)
		PTKc_Tec_like	521..778	CDD:173637	164/257 (64%)
		Pkinase_Tyr	526..777	CDD:285015	160/251 (64%)
tec	XP_031751261.1	PH_Btk	27..168	CDD:269944	46/225 (20%)
		SH3_Tec	204..259	CDD:212838	23/54 (43%)
		SH2_Tec_Itk	262..368	CDD:198259	52/105 (50%)
		PTKc_Tec_Rlk	386..645	CDD:270685	165/261 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1217
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1302
Inparanoid	1	1.050	580	1.000	Inparanoid score	I1012
OMA	1	1.010	-	-		QHG52659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm49323
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.070