DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and ptk6

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_002942429.3	Gene:	ptk6 / 100490792	XenbaseID:	XB-GENE-22069031	Length:	563	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	199/552 - (36%)
Similarity:	283/552 - (51%)	Gaps:	81/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 GGSLGLGGGGGGGGSCTPTSLQPQSSLT-TFKQSPTLLNGNGTLLDANMPGGIPT---------- 329
            |.|..|||.       .|.||...:||| ||..|..|..|...|..::.....|.
Frog    21 GLSRSLGGK-------APQSLHCSASLTSTFFSSNALRVGANVLTQSHFRSPCPLLQGRQRWDEK 78

  Fly   330 --------PGT---PNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVK 383
                    ||.   .|:|.   ||..|..|:|:.|||....:||.:....:||:|.|.: ||.|:
Frog    79 PETLALIFPGNWLDGNAKM---SHRPKRFVSLWDFKAEAPEELSFKVGDVFEVLDRSGD-WWHVQ 139

  Fly   384 DALGN------VGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLL-KQGDKEGCFVVRKSSTK 441
            ...|:      |||:|.|::..:..  :|..||:.|:.||..|.:|| .:|:..|.|::|.|...
Frog   140 KLKGDGKGKPEVGYVPYNFLAEEGT--VEEQEWFFGEKSRTEAVNLLMDEGNTNGSFLIRASDKH 202

  Fly   442 G-LYTLSLHTKVPQSHVKHYHIKQNARCEYYLS------------EKHCCETI-PDLINYHRHNS 492
            | ||.||:.   .|...:|:.|.:|...:::|:            |.:|.:.| |.|
Frog   203 GILYVLSVR---HQDSTRHFKIMRNPEGQFHLNNMTFFPDLKQLVETYCKKPICPGL-------- 256

  Fly   493 GGLACRLKSSPCDRPVPPTAGLSH---DKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVK 554
                  ..:.||.:..|..:.||.   |:||....|..|::.||.|.||.|..|.|:|.:..|||
Frog   257 ------TLTKPCVKNEPVVSDLSPVPLDEWERPREEFTLVKRLGMGNFGQVHEGLWKGKLKVAVK 315

  Fly   555 MMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIG 619
            .:|....|:|.|::|...:..|.|.||:.||.|||...|.|||||.:..|.||||||..||..:.
Frog   316 TIKRDATSQDLFVKETAFLKTLHHKNLLSLYAVCSVGDPYYIVTELVPRGDLLNYLRDLEKDELD 380

  Fly   620 NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTK 684
            ..| .||:..||::||.|||..|.|||||||||.|:|..|:.|:||||:||.:||..|.|: ..:
Frog   381 VEG-QLDIATQVAEGMRYLESQNCIHRDLAARNVLMGRNNICKIADFGMARVILDSYYVSA-SKE 443

  Fly   685 FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCA 749
            .|.||..||.:.|.|::.|||||::|:|::||.:.|..||..|.|.||:|.:.||..::.|.||:
Frog   444 IPFKWTAPEAVEYGRYTVKSDVWSFGILLYEIMSLGMQPYPALSNYEVLEFLNRGQRMKAPPSCS 508

  Fly   750 KEIYDVMKLCWSHGPEERPAF---RVLMDQLA 778
            ..:|::|..||:..|.|||:|   |.:::.|:
Frog   509 TRVYNIMLTCWAWNPNERPSFDDLRTMLENLS 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	20/58 (34%)
		SH2_Tec_family	403..505	CDD:198188	30/116 (26%)
		PTKc_Tec_like	521..778	CDD:173637	116/259 (45%)
		Pkinase_Tyr	526..777	CDD:285015	115/253 (45%)
ptk6	XP_002942429.3	SH3	104..161	CDD:418401	20/57 (35%)
		SH2	168..252	CDD:214585	25/86 (29%)
		STYKc	288..536	CDD:214568	115/249 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920