DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and frk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_002938349.1	Gene:	frk / 100488362	XenbaseID:	XB-GENE-492884	Length:	517	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	191/485 - (39%)
Similarity:	277/485 - (57%)	Gaps:	37/485 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 QSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEV 371
            |:|.:.    |.||...   :|.......:.:.||:     ||||.::.....:||.:...:..:
Frog    37 QNPVIT----TQLDGPQ---VPPRFVNQGEQQRNSY-----VALYSYEGRTPDELSFKAGDQMLI 89

  Fly   372 IDDSQEHWWKVK--DALGNV-GYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLL-KQGDKEGC 432
            ||.:...|||.|  ...|.. ||:|.|||.|  :..:|...|:..|:.|..||.|| :.|:..|.
Frog    90 IDTTHASWWKAKLLRTRGKAEGYVPFNYVAP--VSSIESMPWFFKDIKRSEAERLLVRPGNTTGS 152

  Fly   433 FVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLA 496
            |::|:| |.||.|:||:...:.   ||||.:::.....:|::.|....::.:|:.|:.....||.
Frog   153 FLIRESESQKGEYSLSVFDGIA---VKHYRLRKLDDGGFYITSKSKFVSMNELVEYYGKREEGLC 214

  Fly   497 CRLKSSPC---DRPVPP-----TAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAV 553
            |:| ..||   ..|:||     ||    |.|||:...|..:::||.||||.|..|.|..:|..|:
Frog   215 CKL-LKPCITTGIPLPPDLCYHTA----DHWEINRNSLKFLKKLGQGQFGEVWEGLWNNTIPVAI 274

  Fly   554 KMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLI 618
            |.:|.|||:..||:.||:.|..|:||.|:||..||:...|:||:||.|:|||||:||:....|.|
Frog   275 KTLKTGTMNPQDFLREAQFMKNLRHPKLIQLQAVCTLEEPVYIITELMRHGSLLSYLQNDNGTSI 339

  Fly   619 GNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR-YVLDDQYTSSGG 682
             ::...:||..||:.||.|||..::|||||||||.|||...|.||||||||| :..:|.|.:...
Frog   340 -HIPNQVDMAAQVASGMAYLETQSFIHRDLAARNVLVGENGVYKVADFGLARVFKGEDVYEAKND 403

  Fly   683 TKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKS 747
            ||.|:||..||.:.|.||:.||||||:|:|::||.|.|||||..|...:.:::::.|..:.||.:
Frog   404 TKLPLKWTAPEAIRYNRFTIKSDVWAFGILIFEIVTYGKMPYPGLTGRQALDKLENGYRIPKPFN 468

  Fly   748 CAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |..::|.:|..||:..|||||.|..|..:|
Frog   469 CPHDLYKIMLECWNAKPEERPTFETLQWKL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/55 (35%)
		SH2_Tec_family	403..505	CDD:198188	33/106 (31%)
		PTKc_Tec_like	521..778	CDD:173637	122/258 (47%)
		Pkinase_Tyr	526..777	CDD:285015	120/251 (48%)
frk	XP_002938349.1	SH3_Src_like	65..117	CDD:212779	16/56 (29%)
		SH2	125..220	CDD:387587	31/98 (32%)
		PTKc_Frk_like	238..505	CDD:270653	125/262 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920