DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and fyn

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_004914619.2 Gene:fyn / 100488004 XenbaseID:XB-GENE-6053489 Length:537 Species:Xenopus tropicalis


Alignment Length:494 Identity:204/494 - (41%)
Similarity:292/494 - (59%) Gaps:35/494 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   298 PQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHF----------VKLVVALYP 352
            |..::||.   |...|     ...|...|:...|..||    :||.          |.|.||||.
 Frog    40 PSFTVTTI---PNYNN-----FHTNAGQGLTVFGGVNS----SSHTGTLRTRGGTGVTLFVALYD 92

  Fly   353 FKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMS 416
            ::|....|||.:|..::::::.|:..||:.:. ..|..||||||||.|  :..::..|||.|.:.
 Frog    93 YEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAP--VDSIQAEEWYFGKLG 155

  Fly   417 RQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHIKQNARCEYYLSEKHC 477
            |:.|| .||..|:..|.:::|:| :|||.|:||:.  ..:...|||||.|::.....||::.:..
 Frog   156 RKDAERQLLSFGNPRGTYLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQ 220

  Fly   478 CETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLS---HDKWEIHPMELMLMEELGSGQFGV 539
            .||:..|:.::...:.||.||| ..||.:.:|....||   .|.|||....|.|::.||:||||.
 Frog   221 FETLQQLVQHYSERAAGLCCRL-VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGE 284

  Fly   540 VRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHG 604
            |..|.|.|:...|:|.:|.||||.:.|:|||::|.||:|..|||||.|.|: .|||||||||..|
 Frog   285 VWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMSKG 348

  Fly   605 SLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLA 669
            |||::|:..|...: .:..|:||..||:.||.|:||.|||||||.:.|.|||:..:.|:||||||
 Frog   349 SLLDFLKDGEGRAL-KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLA 412

  Fly   670 RYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVE 734
            |.:.|::||:..|.||||||..||...|.||:.|||||::|:|:.|:.|.|::||..:.|.||:|
 Frog   413 RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLE 477

  Fly   735 RVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVL 773
            :|:||..:..|:.|...::::|..||...|||||.|..|
 Frog   478 QVERGYRMPCPQDCPNSLHELMLNCWKKDPEERPTFEYL 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 22/53 (42%)
SH2_Tec_family 403..505 CDD:198188 36/105 (34%)
PTKc_Tec_like 521..778 CDD:173637 125/253 (49%)
fynXP_004914619.2 SH3_Fyn_Yrk 85..140 CDD:212939 22/54 (41%)
SH2_Src_Fyn_isoform_a_like 145..245 CDD:198281 35/100 (35%)
PTKc_Fyn 261..534 CDD:270655 128/258 (50%)
Blue background indicates that the domain is not in the aligned region.

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