DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and abl2

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_002937405.1	Gene:	abl2 / 100487790	XenbaseID:	XB-GENE-6459814	Length:	1100	Species:	Xenopus tropicalis

Alignment Length:	544	Identity:	208/544 - (38%)
Similarity:	294/544 - (54%)	Gaps:	60/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GSLGGGVGGGLGGGGSLGLGGGGGGG------GSCTPTS---------LQPQSSLTTFKQSPTLL 312
            |...|.|||..........|..|.|.      |:...||         ..|::....|.|...|.
Frog     2 GQQVGRVGGEAPSAQQPHRGARGSGTKPSAHVGNIAATSSRRREATGRTNPETGFNIFTQHEALH 66

  Fly   313 NGNGT------LLDA-------NMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLE 364
            ...|:      |.||       |:.|.  |...||           |.:|||.|.|.....||:.
Frog    67 RPYGSDSEPQALTDAIRWSSKENLLGA--TESDPN-----------LFLALYDFVASGDNTLSIT 118

  Fly   365 KNAEYEVIDDSQE-HWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGD 428
            |..:..|:..:|. .|.:|....|. |::||||:.|  :..||::.||.|.:||..||.|| ...
Frog   119 KGEKLRVLCYNQNGEWCEVLSKNGQ-GWVPSNYITP--VNSLEKHSWYHGPVSRSAAEYLL-SSL 179

  Fly   429 KEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNS 492
            ..|.|:||:| |:.|..::||..   :..|.||.|...:..:.|::.:....|:.:|:::|...:
Frog   180 INGSFLVRESESSPGQLSISLRY---EGRVYHYRINTASDGKVYVTAESRFNTLAELVHHHSTVA 241

  Fly   493 GGLACRL--KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG-SIDTAVK 554
            .||...|  .:..|::|........|||||:...::.:..:||.||:|.|..|.|:. ::..|||
Frog   242 DGLVTILHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYNLTVAVK 306

  Fly   555 MMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLR---RHEKT 616
            .:||.||..::|::||.||.:::|||||||.|||:...|.|||||||.:|:||:|||   |.|.|
Frog   307 TLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMHYGNLLDYLRECNREEVT 371

  Fly   617 LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSG 681
            .:    :||.|..|:|..|.||||.|:|||||||||||||..:|||||||||:|.:..|.||:..
Frog   372 AV----VLLYMATQISSAMEYLERKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA 432

  Fly   682 GTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPK 746
            |.||||||..||.|.|..||.||||||:|||:|||.|.|..||..:..::|.:.:::|..:|:|:
Frog   433 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPE 497

  Fly   747 SCAKEIYDVMKLCWSHGPEERPAF 770
            .|..::|::|:.||...|.:||:|
Frog   498 GCPPKVYELMRACWQWNPSDRPSF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/53 (36%)
		SH2_Tec_family	403..505	CDD:198188	31/104 (30%)
		PTKc_Tec_like	521..778	CDD:173637	126/254 (50%)
		Pkinase_Tyr	526..777	CDD:285015	126/249 (51%)
abl2	XP_002937405.1	SH3_Abl	100..153	CDD:212784	19/53 (36%)
		SH2_ABL	158..251	CDD:198189	30/96 (31%)
		PTKc_Abl	270..532	CDD:270645	128/256 (50%)
		F_actin_bind	984..1100	CDD:385063
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910