Protein Alignment Btk and Tyk2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001244276.1
• Gene: Tyk2 / 100361294
• RGDID: 2320469
• Length: 1186
• Species: Rattus norvegicus
• Alignment Length: 888
• Identity: 209/888 - (23%)
• Similarity: 312/888 - (35%)
• Gaps: 245/888 - (27%)

  Fly    55 KKRFTPVNYKHRWFELTKRTFSYF----DVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAP 115
            ||...|.:.:|......:..::||    |:.:|..:..|..|||:..:.:.....|......|..
  Rat   355 KKPKAPESGEHLAGSPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVA 419

  Fly   116 --DGYPFQVGYCEISASANSHQL-------------ENGNGGGSGVGIEGQQSGRAVPQYTLYVI 165
              ||| |::      .:.:||.|             :||..|..   ::.....:..|:..||:|
  Rat   420 LVDGY-FRL------TADSSHYLCHEVAPPRLVTSIQNGIHGPL---MDPFVQAKLWPEDGLYLI 474

  Fly   166 ANSEKERSEWIRAIRQVCE----DSNTPKSYR-------YHPGL-----WSGKKWSCCKGLSRTT 214
               :...|...|.|..|..    ..|.|:..|       ..||.     | |:.:.....|.:..
  Rat   475 ---QWSTSHLHRLILTVAHRNPASRNGPRGLRLRKFPITQQPGAFVLDGW-GRSFDSLGDLRQAL 535

  Fly   215 FGCRAAA--------HW-----REANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLG 266
            .||...|        |.     ||.:|......|.|.....::|..|      |...|....:..
  Rat   536 QGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLS------FHRVHQDEITQL 594

  Fly   267 GGVGGGLGGG---GSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIP 328
            ..:|.|....   |.|.:||...|                              .:|:..|.| |
  Rat   595 SHLGQGTRTNVYEGLLSVGGPNEG------------------------------KVDSGCPSG-P 628

  Fly   329 TPGTPNS-----KAKDNSHFVKLVVALYPFKAI--EGGDLSLE-------KNAEYEVIDDSQEH- 378
            ..|:...     |..|.||. .:.:|.|...::  :...:.|.       :.:|..::.:..||
  Rat   629 DRGSGQQLRVVLKVLDPSHH-DIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVAEFVEHG 692

  Fly   379 ----W-----------WK--VKDALGNVGYIPSNYVKPK--------------ALLGL------- 405
                |           ||  |...|.:.    .:|::.|              |.|||
  Rat   693 PLDVWLRRQRGRVPMPWKMVVAQQLASA----LSYLEDKNLVHGNVCGRNILLARLGLEEGTNPF 753

  Fly   406 -------------------ERYEWYVGDMSRQRAESLLKQGDKEG--------CF------VVRK 437
                               ||..|...:.....|.||....|..|        ||      ..|.
  Rat   754 IKLSDPGVGQGALSREERVERIPWTAPECLSGGANSLGTATDMWGFGATLLEICFDGEAPLQGRG 818

  Fly   438 SSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETI-PDLINYHRHNSGGLACRLKS 501
            .|.|..:....| ::|:...............|..:::....|| .||......|..|.:.....
  Rat   819 PSEKERFYTKKH-QLPEPSCPELATLTRQCLSYEPAQRPSFRTILRDLTRLQPQNLVGTSTVNSD 882

  Fly   502 SPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSID-----TAVKMMKE--G 559
            ||...|.           ..|...|..:.:||.|.||.|....:..:.|     .|||.:||  |
  Rat   883 SPASDPT-----------VFHKRYLKRIRDLGEGHFGKVSLYCYDPNNDGTGEMVAVKALKEGCG 936

  Fly   560 TMSEDDFIEEAKVMTKLQHPNLVQLYGVCSK--HRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
            ......:..|.:::..|.|.::|:..|.|..  .:.:.:|.||:..|||.:||.||.   :|...
  Rat   937 PQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHS---VGLAQ 998

  Fly   623 LLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLD--DQYTSSGGTKF 685
            ||| ...|:.:||.||...:||||||||||.|:.::.:||:.|||||:.|.:  :.|........
  Rat   999 LLL-FAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 1062

  Fly   686 PIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-C------------------GKMPYGRLKNTE 731
            |:.|..||.|...:|...||||::||.::|:.| |                  |:|...||  ||
  Rat  1063 PVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSSQSPPTKFIELIGVTQGQMTVLRL--TE 1125

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLM 774
            ::||.:|   |.:|..|..|||.:||.||......||.|:.|:
  Rat  1126 LLERGER---LPRPDRCPCEIYHLMKNCWESEASFRPTFQNLV 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	43/209 (21%)
		SH3_Tec_like	346..399	CDD:212702	12/79 (15%)
		SH2_Tec_family	403..505	CDD:198188	27/142 (19%)
		PTKc_Tec_like	521..778	CDD:173637	98/284 (35%)
Tyk2	NP_001244276.1	FERM_F1	33..130	CDD:465733
		FERM_F2	148..271	CDD:436450
		Jak1_Phl	290..433	CDD:465552	18/84 (21%)
		SH2	438..536	CDD:472789	19/104 (18%)
		Protein Kinases, catalytic domain	591..866	CDD:473864	52/311 (17%)
		PTKc_Tyk2_rpt2	891..1173	CDD:270664	98/284 (35%)