DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and Tyk2

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001244276.1	Gene:	Tyk2 / 100361294	RGDID:	2320469	Length:	1186	Species:	Rattus norvegicus

Alignment Length:	888	Identity:	209/888 - (23%)
Similarity:	312/888 - (35%)	Gaps:	245/888 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KKRFTPVNYKHRWFELTKRTFSYF----DVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAP 115
            ||...|.:.:|......:..::||    |:.:|..:..|..|||:..:.:.....|......|..
  Rat   355 KKPKAPESGEHLAGSPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVA 419

  Fly   116 --DGYPFQVGYCEISASANSHQL-------------ENGNGGGSGVGIEGQQSGRAVPQYTLYVI 165
              ||| |::      .:.:||.|             :||..|..   ::.....:..|:..||:|
  Rat   420 LVDGY-FRL------TADSSHYLCHEVAPPRLVTSIQNGIHGPL---MDPFVQAKLWPEDGLYLI 474

  Fly   166 ANSEKERSEWIRAIRQVCE----DSNTPKSYR-------YHPGL-----WSGKKWSCCKGLSRTT 214
               :...|...|.|..|..    ..|.|:..|       ..||.     | |:.:.....|.:..
  Rat   475 ---QWSTSHLHRLILTVAHRNPASRNGPRGLRLRKFPITQQPGAFVLDGW-GRSFDSLGDLRQAL 535

  Fly   215 FGCRAAA--------HW-----REANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLG 266
            .||...|        |.     ||.:|......|.|.....::|..|      |...|....:..
  Rat   536 QGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLS------FHRVHQDEITQL 594

  Fly   267 GGVGGGLGGG---GSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIP 328
            ..:|.|....   |.|.:||...|                              .:|:..|.| |
  Rat   595 SHLGQGTRTNVYEGLLSVGGPNEG------------------------------KVDSGCPSG-P 628

  Fly   329 TPGTPNS-----KAKDNSHFVKLVVALYPFKAI--EGGDLSLE-------KNAEYEVIDDSQEH- 378
            ..|:...     |..|.||. .:.:|.|...::  :...:.|.       :.:|..::.:..||
  Rat   629 DRGSGQQLRVVLKVLDPSHH-DIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVAEFVEHG 692

  Fly   379 ----W-----------WK--VKDALGNVGYIPSNYVKPK--------------ALLGL------- 405
                |           ||  |...|.:.    .:|::.|              |.|||
  Rat   693 PLDVWLRRQRGRVPMPWKMVVAQQLASA----LSYLEDKNLVHGNVCGRNILLARLGLEEGTNPF 753

  Fly   406 -------------------ERYEWYVGDMSRQRAESLLKQGDKEG--------CF------VVRK 437
                               ||..|...:.....|.||....|..|        ||      ..|.
  Rat   754 IKLSDPGVGQGALSREERVERIPWTAPECLSGGANSLGTATDMWGFGATLLEICFDGEAPLQGRG 818

  Fly   438 SSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETI-PDLINYHRHNSGGLACRLKS 501
            .|.|..:....| ::|:...............|..:::....|| .||......|..|.:.....
  Rat   819 PSEKERFYTKKH-QLPEPSCPELATLTRQCLSYEPAQRPSFRTILRDLTRLQPQNLVGTSTVNSD 882

  Fly   502 SPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSID-----TAVKMMKE--G 559
            ||...|.           ..|...|..:.:||.|.||.|....:..:.|     .|||.:||  |
  Rat   883 SPASDPT-----------VFHKRYLKRIRDLGEGHFGKVSLYCYDPNNDGTGEMVAVKALKEGCG 936

  Fly   560 TMSEDDFIEEAKVMTKLQHPNLVQLYGVCSK--HRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622
            ......:..|.:::..|.|.::|:..|.|..  .:.:.:|.||:..|||.:||.||.   :|...
  Rat   937 PQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHS---VGLAQ 998

  Fly   623 LLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLD--DQYTSSGGTKF 685
            ||| ...|:.:||.||...:||||||||||.|:.::.:||:.|||||:.|.:  :.|........
  Rat   999 LLL-FAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 1062

  Fly   686 PIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-C------------------GKMPYGRLKNTE 731
            |:.|..||.|...:|...||||::||.::|:.| |                  |:|...||  ||
  Rat  1063 PVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSSQSPPTKFIELIGVTQGQMTVLRL--TE 1125

  Fly   732 VVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLM 774
            ::||.:|   |.:|..|..|||.:||.||......||.|:.|:
  Rat  1126 LLERGER---LPRPDRCPCEIYHLMKNCWESEASFRPTFQNLV 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	43/209 (21%)
		SH3_Tec_like	346..399	CDD:212702	12/79 (15%)
		SH2_Tec_family	403..505	CDD:198188	27/142 (19%)
		PTKc_Tec_like	521..778	CDD:173637	98/284 (35%)
		Pkinase_Tyr	526..777	CDD:285015	97/279 (35%)
Tyk2	NP_001244276.1	FERM_F1	33..130	CDD:408179
		FERM_F2	148..271	CDD:408177
		Jak1_Phl	290..433	CDD:407742	18/84 (21%)
		SH2	438..536	CDD:417686	19/104 (18%)
		PKc_like	591..866	CDD:419665	52/311 (17%)
		PTKc_Tyk2_rpt2	891..1173	CDD:270664	98/284 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810