Protein Alignment Btk and si:ch73-340m8.2

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_002665190.3
• Gene: si:ch73-340m8.2 / 100332982
• ZFINID: ZDB-GENE-110411-209
• Length: 480
• Species: Danio rerio
• Alignment Length: 474
• Identity: 163/474 - (34%)
• Similarity: 249/474 - (52%)
• Gaps: 34/474 - (7%)

  Fly   332 TPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWW----------KVKDAL 386
            |.:.:|..|...|...:..||.:.|  .||:|.|....||..:: |:|.          |.|..:
Zfish    20 TKDQQASVNRDRVYTSIYSYPSRTI--WDLNLRKGDILEVTGET-EYWLYVRRRTAKTDKSKSFI 81

  Fly   387 GNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAES---LLKQGDKEGCFVVRKSSTKGLYTLSL 448
            ...||:|.::|||  |..:|...||..:: :.|.|:   ||:..:|||.|:|.|......|.||:
Zfish    82 EEHGYVPKDFVKP--LDSVEAEPWYFENV-KTRVEAKRCLLRPENKEGAFLVWKCDENNHYYLSV 143

  Fly   449 HTKVPQSHVKHYHIKQNARCEYYLSEKHCC-ETIPDLINYHRHNSGGLACRLKSSPC---DRPVP 509
            ..   ..|.:||.|||....:.:....|.. :::..||.::..:.|||..:|..: |   |:|||
Zfish   144 KN---GPHARHYRIKQGENDQQFFLVHHTTFQSLRKLIEFYSKHEGGLCAKLHEA-CVKLDQPVP 204

  Fly   510 PTAGLSHD-KWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVM 573
            .|  ||.| |.||....|...::||||:|..|.:|.|..:.:.|:|..|  .::..|...|.::|
Zfish   205 QT--LSFDSKCEIDRSSLTKQQKLGSGEFADVWQGLWNNTTEVAIKEFK--GVNYSDIQTEIEIM 265

  Fly   574 TKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYL 638
            ..|.|..|::||.||:..:|:.||||.||:|||..:|.||::.......|:||..||:::||.|:
Zfish   266 KDLHHERLLKLYAVCTTSQPMCIVTELMKNGSLKTFLLRHKEKQDLEFSLMLDFAIQITEGMIYI 330

  Fly   639 ERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSK 703
            | :..:||||.|.|.|:......|:||||||:.........|...:.|:||..||:.:...::||
Zfish   331 E-NKIVHRDLRAENILLTEMQSCKIADFGLAQVNRPGNQRISSDVRLPVKWMAPEIFDNGEYTSK 394

  Fly   704 SDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERP 768
            ||||::|:|:.||.|.|..||........|..:|||..:.:|..|.:.:|.:|.|||...|:|||
Zfish   395 SDVWSFGILLTEIVTYGDDPYPGQDKMSCVRGIQRGERMPRPAGCPESLYGIMLLCWKANPKERP 459

  Fly   769 AFRVLMDQL-ALVAQTLTD 786
            .|..|.:.| ||:.:.:::
Zfish   460 TFTELREMLMALIHEPVSE 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/62 (27%)
		SH2_Tec_family	403..505	CDD:198188	30/108 (28%)
		PTKc_Tec_like	521..778	CDD:173637	97/257 (38%)
si:ch73-340m8.2	XP_002665190.3	SH2	99..192	CDD:472789	28/96 (29%)
		Protein Kinases, catalytic domain	225..468	CDD:473864	94/245 (38%)