DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and si:ch73-340m8.2

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	XP_002665190.3	Gene:	si:ch73-340m8.2 / 100332982	ZFINID:	ZDB-GENE-110411-209	Length:	480	Species:	Danio rerio

Alignment Length:	474	Identity:	163/474 - (34%)
Similarity:	249/474 - (52%)	Gaps:	34/474 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 TPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWW----------KVKDAL 386
            |.:.:|..|...|...:..||.:.|  .||:|.|....||..:: |:|.          |.|..:
Zfish    20 TKDQQASVNRDRVYTSIYSYPSRTI--WDLNLRKGDILEVTGET-EYWLYVRRRTAKTDKSKSFI 81

  Fly   387 GNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAES---LLKQGDKEGCFVVRKSSTKGLYTLSL 448
            ...||:|.::|||  |..:|...||..:: :.|.|:   ||:..:|||.|:|.|......|.||:
Zfish    82 EEHGYVPKDFVKP--LDSVEAEPWYFENV-KTRVEAKRCLLRPENKEGAFLVWKCDENNHYYLSV 143

  Fly   449 HTKVPQSHVKHYHIKQNARCEYYLSEKHCC-ETIPDLINYHRHNSGGLACRLKSSPC---DRPVP 509
            ..   ..|.:||.|||....:.:....|.. :::..||.::..:.|||..:|..: |   |:|||
Zfish   144 KN---GPHARHYRIKQGENDQQFFLVHHTTFQSLRKLIEFYSKHEGGLCAKLHEA-CVKLDQPVP 204

  Fly   510 PTAGLSHD-KWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVM 573
            .|  ||.| |.||....|...::||||:|..|.:|.|..:.:.|:|..|  .::..|...|.::|
Zfish   205 QT--LSFDSKCEIDRSSLTKQQKLGSGEFADVWQGLWNNTTEVAIKEFK--GVNYSDIQTEIEIM 265

  Fly   574 TKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYL 638
            ..|.|..|::||.||:..:|:.||||.||:|||..:|.||::.......|:||..||:::||.|:
Zfish   266 KDLHHERLLKLYAVCTTSQPMCIVTELMKNGSLKTFLLRHKEKQDLEFSLMLDFAIQITEGMIYI 330

  Fly   639 ERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSK 703
            | :..:||||.|.|.|:......|:||||||:.........|...:.|:||..||:.:...::||
Zfish   331 E-NKIVHRDLRAENILLTEMQSCKIADFGLAQVNRPGNQRISSDVRLPVKWMAPEIFDNGEYTSK 394

  Fly   704 SDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERP 768
            ||||::|:|:.||.|.|..||........|..:|||..:.:|..|.:.:|.:|.|||...|:|||
Zfish   395 SDVWSFGILLTEIVTYGDDPYPGQDKMSCVRGIQRGERMPRPAGCPESLYGIMLLCWKANPKERP 459

  Fly   769 AFRVLMDQL-ALVAQTLTD 786
            .|..|.:.| ||:.:.:::
Zfish   460 TFTELREMLMALIHEPVSE 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/62 (27%)
		SH2_Tec_family	403..505	CDD:198188	30/108 (28%)
		PTKc_Tec_like	521..778	CDD:173637	97/257 (38%)
		Pkinase_Tyr	526..777	CDD:285015	95/250 (38%)
si:ch73-340m8.2	XP_002665190.3	SH2	99..192	CDD:301589	28/96 (29%)
		Pkinase_Tyr	220..468	CDD:285015	95/250 (38%)
		PKc_like	225..468	CDD:304357	94/245 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810