Protein Alignment Btk and fgfr3

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_012812743.1
• Gene: fgfr3 / 100196923
• XenbaseID: XB-GENE-479255
• Length: 829
• Species: Xenopus tropicalis
• Alignment Length: 304
• Identity: 109/304 - (35%)
• Similarity: 162/304 - (53%)
• Gaps: 33/304 - (10%)

  Fly   513 GLSHD-KWEIHPMELMLMEELGSGQFGVVRRGKWRG--------SIDTAVKMMKEGTMSED--DF 566
            ||..| |||:....|.|.:.||.|.||.|...:..|        .:..||||:|:....:|  |.
 Frog   475 GLPLDPKWELLRTRLTLGKPLGEGCFGQVVMAEAIGIEKERPNKPVTVAVKMLKDDATDKDLSDL 539

  Fly   567 IEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMC-- 628
            :.|.::|..: :|.|::.|.|.|::..|:|::.||...|:|..||:.....   .|....|.|
 Frog   540 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLKARRPP---GMDYSFDTCKI 601

  Fly   629 --------------IQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLD-DQYT 678
                          .||::||.||.....|||||||||.||..:||:|:|||||||.:.: |.|.
 Frog   602 PAEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDIHNIDYYK 666

  Fly   679 SSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILE 743
            .:...:.|:||..||.|....::.:||||:||||:||.||.|..||..:...|:.:.::.|..::
 Frog   667 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKLLKEGHRMD 731

  Fly   744 KPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL-ALVAQTLTD 786
            ||.:|..|:|.:|:.||...|.:||.|:.|::.| .::..|.||
 Frog   732 KPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLTVTSTD 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	100/285 (35%)
fgfr3	XP_012812743.1	Ig	<75..128	CDD:472250
		Ig strand B	78..82	CDD:409353
		Ig strand C	90..94	CDD:409353
		Ig strand E	111..115	CDD:409353
		IgI_2_FGFR	167..261	CDD:409443
		Ig strand A	167..170	CDD:409443
		Ig strand A'	178..183	CDD:409443
		Ig strand B	187..195	CDD:409443
		Ig strand C	201..206	CDD:409443
		Ig strand C'	209..211	CDD:409443
		Ig strand D	220..223	CDD:409443
		Ig strand E	227..232	CDD:409443
		Ig strand F	241..248	CDD:409443
		Ig strand G	251..261	CDD:409443
		IgI_3_FGFR	269..369	CDD:409363
		Ig strand A	269..272	CDD:409363
		Ig strand A'	276..280	CDD:409363
		Ig strand B	288..295	CDD:409363
		Ig strand C	299..306	CDD:409363
		Ig strand D	321..326	CDD:409363
		Ig strand E	336..341	CDD:409363
		Ig strand F	349..357	CDD:409363
		Ig strand G	360..368	CDD:409363
		PTKc_FGFR3	476..809	CDD:173652	108/303 (36%)