Protein Alignment Btk and srms

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_001129722.2
• Gene: srms / 100192213
• ZFINID: ZDB-GENE-081022-95
• Length: 492
• Species: Danio rerio
• Alignment Length: 460
• Identity: 179/460 - (38%)
• Similarity: 260/460 - (56%)
• Gaps: 26/460 - (5%)

  Fly   325 GGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNV 389
            |.|..| .|..|.      .:|..||:.|.|....:||:::..:..||:...::.: .|...|::
Zfish    38 GDIRVP-APKKKP------AQLYAALFDFVARSEEELSVKEGDKLSVIEKRGDYVF-AKKLTGSL 94

  Fly   390 --GYIPSNYVKPKALLGLE--RYEWYVGDMSRQRAESLLKQGD-KEGCFVVRKS-STKGLYTLSL 448
              |.||:|||   |||..|  .|:||.|:::||:||.||...: |.|.|:||.| |....||:|.
Zfish    95 ESGLIPANYV---ALLKDEFANYKWYYGNINRQKAEKLLLSSENKTGSFLVRISESHSDEYTISA 156

  Fly   449 HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAG 513
            .:   ::.|.|:.|.::....|::|||....|:.:||.|::.||..|.|.: ..||   |.....
Zfish   157 RS---ENSVFHFRIHRSPIGAYFVSEKISFGTLDELIRYYQQNSRSLGCHI-DQPC---VQRREL 214

  Fly   514 LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR-GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQ 577
            ...:.||....|.||:::||.|.||.|....|: .....|:||:|:.....|:|::|...:..|.
Zfish   215 FDMEPWERPREEFMLVKKLGEGHFGEVWEAIWKTQKKKVAIKMLKQEDTKLDEFVKEVHALKNLH 279

  Fly   578 HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN 642
            ||.|::|..:||:..|:|||||.|..|||.:||...|..|:.:..|:. |..|:::||.|||..:
Zfish   280 HPKLIELLALCSRGEPVYIVTELMAKGSLKSYLSSAEGQLLTSAHLIY-MAAQIAEGMAYLEDRH 343

  Fly   643 YIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVW 707
            .:||||||||.|||::.|.|||||||||.:.|..:|:|..||.|::|..||...|.|||.|||||
Zfish   344 IVHRDLAARNILVGNDLVCKVADFGLARIIKDSVFTASKTTKIPVRWTAPEAALYQRFSVKSDVW 408

  Fly   708 AYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRV 772
            ::|||::|:.:.|||||....|.||:|.:..|..|..|..|...||.:|..||::...:||:|..
Zfish   409 SFGVLLYEMMSRGKMPYDGKTNKEVMEALSSGYRLACPNHCPPNIYRIMLECWNNEASKRPSFHA 473

  Fly   773 LMDQL 777
            |..||
Zfish   474 LHSQL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/54 (31%)
		SH2_Tec_family	403..505	CDD:198188	38/105 (36%)
		PTKc_Tec_like	521..778	CDD:173637	113/258 (44%)
srms	NP_001129722.2	SH3	52..106	CDD:473055	17/57 (30%)
		SH2	116..193	CDD:425423	29/79 (37%)
		Protein Kinases, catalytic domain	220..481	CDD:473864	115/260 (44%)