DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and srms

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001129722.2	Gene:	srms / 100192213	ZFINID:	ZDB-GENE-081022-95	Length:	492	Species:	Danio rerio

Alignment Length:	460	Identity:	179/460 - (38%)
Similarity:	260/460 - (56%)	Gaps:	26/460 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 GGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNV 389
            |.|..| .|..|.      .:|..||:.|.|....:||:::..:..||:...::.: .|...|::
Zfish    38 GDIRVP-APKKKP------AQLYAALFDFVARSEEELSVKEGDKLSVIEKRGDYVF-AKKLTGSL 94

  Fly   390 --GYIPSNYVKPKALLGLE--RYEWYVGDMSRQRAESLLKQGD-KEGCFVVRKS-STKGLYTLSL 448
              |.||:|||   |||..|  .|:||.|:::||:||.||...: |.|.|:||.| |....||:|.
Zfish    95 ESGLIPANYV---ALLKDEFANYKWYYGNINRQKAEKLLLSSENKTGSFLVRISESHSDEYTISA 156

  Fly   449 HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAG 513
            .:   ::.|.|:.|.::....|::|||....|:.:||.|::.||..|.|.: ..||   |.....
Zfish   157 RS---ENSVFHFRIHRSPIGAYFVSEKISFGTLDELIRYYQQNSRSLGCHI-DQPC---VQRREL 214

  Fly   514 LSHDKWEIHPMELMLMEELGSGQFGVVRRGKWR-GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQ 577
            ...:.||....|.||:::||.|.||.|....|: .....|:||:|:.....|:|::|...:..|.
Zfish   215 FDMEPWERPREEFMLVKKLGEGHFGEVWEAIWKTQKKKVAIKMLKQEDTKLDEFVKEVHALKNLH 279

  Fly   578 HPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN 642
            ||.|::|..:||:..|:|||||.|..|||.:||...|..|:.:..|:. |..|:::||.|||..:
Zfish   280 HPKLIELLALCSRGEPVYIVTELMAKGSLKSYLSSAEGQLLTSAHLIY-MAAQIAEGMAYLEDRH 343

  Fly   643 YIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVW 707
            .:||||||||.|||::.|.|||||||||.:.|..:|:|..||.|::|..||...|.|||.|||||
Zfish   344 IVHRDLAARNILVGNDLVCKVADFGLARIIKDSVFTASKTTKIPVRWTAPEAALYQRFSVKSDVW 408

  Fly   708 AYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRV 772
            ::|||::|:.:.|||||....|.||:|.:..|..|..|..|...||.:|..||::...:||:|..
Zfish   409 SFGVLLYEMMSRGKMPYDGKTNKEVMEALSSGYRLACPNHCPPNIYRIMLECWNNEASKRPSFHA 473

  Fly   773 LMDQL 777
            |..||
Zfish   474 LHSQL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	17/54 (31%)
		SH2_Tec_family	403..505	CDD:198188	38/105 (36%)
		PTKc_Tec_like	521..778	CDD:173637	113/258 (44%)
		Pkinase_Tyr	526..777	CDD:285015	110/251 (44%)
srms	NP_001129722.2	SH3	52..106	CDD:302595	17/57 (30%)
		SH2	114..197	CDD:214585	31/85 (36%)
		PKc_like	220..481	CDD:304357	115/260 (44%)
		STYKc	229..478	CDD:214568	109/249 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810