DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and jak3

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_001107517.1	Gene:	jak3 / 100135373	XenbaseID:	XB-GENE-5904698	Length:	1107	Species:	Xenopus tropicalis

Alignment Length:	325	Identity:	106/325 - (32%)
Similarity:	158/325 - (48%)	Gaps:	51/325 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 GGLACRLKSSPCDRPVPPTAGLSHDKWEI------HPMELMLMEELGSGQFGVVR------RGKW 545
            |||..      ||.           .||:      ....|..:..||.|.||.|.      .|..
Frog   799 GGLRV------CDH-----------AWELQDPTVYEERHLKYISVLGKGNFGSVELCRYDPLGDN 846

  Fly   546 RGSIDTAVKMMKEGTMSE-DDFIEEAKVMTKLQHPNLVQLYGVC--SKHRPIYIVTEYMKHGSLL 607
            .|.: .|||.::..|:.. .||..|::::..|....:|:..|:|  :..|...::.||:.:|||.
Frog   847 TGEL-VAVKKLQHHTVEHVRDFQRESRILRSLHSDFIVKYKGICYSAGRRSFQLIMEYLPNGSLR 910

  Fly   608 NYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV 672
            .||.:::..| |...||| ...|:.|||.||....|:|||||:||.||.|...||:.||||.:.:
Frog   911 EYLPKNQNVL-GPCHLLL-YASQICKGMLYLGSQRYVHRDLASRNVLVESREHVKIGDFGLTKIL 973

  Fly   673 LDDQ--YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGK------MPYGRLKN 729
            ..|:  |......:.||.|..||.|:.:.:|.:||||::|||::|:||..:      ..|.|:..
Frog   974 PQDKEYYVVREKGESPIFWHAPESLSDSIYSRESDVWSFGVLLYELFTYSQRSCSPPTEYLRMMG 1038

  Fly   730 --------TEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786
                    ..:||.::.|..|..|.||..|:|.:|..|||..|.|||:|:.|..|:..:.::||:
Frog  1039 PHNAQQTVCSLVEFLRAGKRLCTPASCPTEVYKLMLSCWSSLPSERPSFKDLELQVEQLQESLTN 1103

Fly 787 786
Frog 1104 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	3/11 (27%)
		PTKc_Tec_like	521..778	CDD:173637	97/287 (34%)
		Pkinase_Tyr	526..777	CDD:285015	96/275 (35%)
jak3	NP_001107517.1	B41	39..259	CDD:214604
		FERM_B-lobe	139..250	CDD:271216
		FERM_C_JAK3	255..364	CDD:275413
		SH2_Jak3	364..459	CDD:198243
		PTK_Jak3_rpt1	520..779	CDD:271110
		Pkinase_Tyr	520..778	CDD:285015
		PTKc_Jak3_rpt2	816..1098	CDD:270665	97/284 (34%)
		TyrKc	821..1097	CDD:197581	97/278 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000