Protein Alignment Btk and mst1ra

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: XP_005166175.1
• Gene: mst1ra / 100002448
• ZFINID: ZDB-GENE-071218-2
• Length: 1356
• Species: Danio rerio
• Alignment Length: 787
• Identity: 194/787 - (24%)
• Similarity: 279/787 - (35%)
• Gaps: 277/787 - (35%)

  Fly    73 RTFSYF---DVENVERR---RERGRIHLKGVRL--VEEATVSGEGG--DPFAPDGYPFQVGYCEI 127
            :||||.   :|..|...   |...:|.:.|..|  |.:|.:..:||  ||
Zfish   735 KTFSYRVNPEVTGVNPNCGFRRGSKIIITGQNLDSVSQAVIKYKGGYKDP--------------- 784

  Fly   128 SASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSY 192
                                :|...||:..|..               :..:..|||:|.
Zfish   785 --------------------VETVCSGQGNPTQ---------------MECMSPVCEEST----- 809

  Fly   193 RYHPGLWS----GKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTR--SISPNSSTT 251
                |:.|    |     .|.|...||.|       .||..|    .|.:...|  .:||.
Zfish   810 ----GILSVDLDG-----AKDLQSQTFTC-------HANGEP----IPFETEDRVLELSPG---- 850

  Fly   252 NSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNG-- 314
            ..:.||.|.....:.|                       |....:              .:||
Zfish   851 QDEVSLHHKKLALVSG-----------------------CMEIIM--------------TVNGVD 878

  Fly   315 -NGTLLD----ANMPGG--IPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVI 372
             |..:||    ..:|..  ||..|.|          ||::|
Zfish   879 CNAKVLDNEITCRIPKNLTIPRQGAP----------VKVLV------------------------ 909

  Fly   373 DDSQEHWWKVKDALGNVGYIPSNYVKPKAL-----LGLERYEWYVGDMSRQRAESLLKQGDKEGC 432
             :.:||      .:|.|....||.:....|     :|:.....||. |:::|.:.      |...
Zfish   910 -NREEH------DIGMVVMKNSNLIVGVVLGILAAVGVGAAIVYVA-MAQERKKK------KAAL 960

  Fly   433 FVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHR-------- 489
            ..||         ||:|:             .....|.|       :..|| .:|.|
Zfish   961 VEVR---------LSMHS-------------NRTTAENY-------DRSPD-GDYRRETVRPAGL 995

  Fly   490 -----HNSGGLACRL--------KSSPCDRPVPPTAGLSHDKWE------IHPMELMLMEE--LG 533
                 |.||.....|        .::|..|.....:.|..|..|      |.|.::.:..|  :|
Zfish   996 SVSPFHGSGTTFTSLPYAGSMDSAAAPLMRRQVSMSALRPDLLEEVKNVLISPDKIKIQHEQIIG 1060

  Fly   534 SGQFGVVRRGKWRGS----IDTAVKMMKEGTMSE--DDFIEEAKVMTKLQHPNLVQLYGVC--SK 590
            .|.||.|..|....|    ...|||.:...|..|  :.|:.|...|....|.:::.|.|:.  |.
Zfish  1061 KGHFGTVYHGYLTDSDNKETHCAVKSLNRITDLEEVEQFLREGLFMKAFHHSHVLSLLGIVLPSD 1125

  Fly   591 HRPIYIVTEYMKHGSLLNYLRRHE-----KTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAA 650
            ..|: ::..|||||.|.:::|..|     |.||| .||      ||:|||.||....::||||||
Zfish  1126 GLPL-VILPYMKHGDLRHFIRSPERSPTVKDLIG-FGL------QVAKGMEYLANKKFVHRDLAA 1182

  Fly   651 RNCLVGSENVVKVADFGLARYVLDDQYTS---SGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVL 712
            |||::.....|||||||:||.|.|.:|.|   |...|.|:||...|.|...:|::|||||:||||
Zfish  1183 RNCMLDESFTVKVADFGMARDVYDKEYYSIQDSKKAKLPVKWMALESLQTQKFTTKSDVWSYGVL 1247

  Fly   713 MWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |||:.|.|..||..:...::...:.:|..|.:|:.|...::.|:..||...||:||.|..|:..:
Zfish  1248 MWELLTRGASPYPDVDPYDITPYLMQGRRLPQPQYCFDSLWSVLMQCWHPEPEKRPGFTTLVQAV 1312

  Fly   778 ALVAQTL 784
            ..:..:|
Zfish  1313 QDIHSSL 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	32/162 (20%)
		SH3_Tec_like	346..399	CDD:212702	7/52 (13%)
		SH2_Tec_family	403..505	CDD:198188	22/122 (18%)
		PTKc_Tec_like	521..778	CDD:173637	103/274 (38%)
mst1ra	XP_005166175.1	Sema_MET_like	41..504	CDD:200509
		PSI	507..549	CDD:396154
		IPT	550..654	CDD:472823
		IPT_plexin_repeat2	655..740	CDD:238584	3/4 (75%)
		IPT	742..828	CDD:214657	26/149 (17%)
		PTKc_Met_Ron	1057..1318	CDD:270649	100/268 (37%)