DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8086 and NUP159

DIOPT Version :9

Sequence 1:	NP_001260237.1	Gene:	CG8086 / 34131	FlyBaseID:	FBgn0032010	Length:	1603	Species:	Drosophila melanogaster
Sequence 2:	NP_012151.1	Gene:	NUP159 / 854691	SGDID:	S000001377	Length:	1460	Species:	Saccharomyces cerevisiae

Alignment Length:	995	Identity:	205/995 - (20%)
Similarity:	318/995 - (31%)	Gaps:	321/995 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 SFGHRAELAKSSD-TPAPGTYNPEKVRLDHTPAFTLSGRPETRSVSETPAPGSYAPEKYRNDRTP 415
            |..|...|:.:|: .|..|....||.:          ....::::||.|         :.:..|.
Yeast   396 SLEHEKSLSPTSEKIPIAGQEQEEKKK----------NNESSKALSENP---------FTSANTS 441

  Fly   416 AFTFGGKHEQRLESSTPAPGDYCPEKVRHDHNPAF-SFAGRHDLHKPSDTPAPGAYDTEKVRQDH 479
            .|||       |::...|......:.......|:| |.|.:.||...|.| :.|...:|:...|.
Yeast   442 GFTF-------LKTQPAAANSLQSQSSSTFGAPSFGSSAFKIDLPSVSST-STGVASSEQDATDP 498

  Fly   480 NPAFSFAGRHDLHKPSETPAPGAYSPEKVRQDH---NPAFSMAGKHSQKVTSDSPAPGDYCPEKV 541
            ..|....|:         ||.||.:.|....::   .|:|......|.|.:.:|||.|....:
Yeast   499 ASAKPVFGK---------PAFGAIAKEPSTSEYAFGKPSFGAPSFGSGKSSVESPASGSAFGK-- 552

  Fly   542 RLDHTPAY---SFGVKSDPKVENNTPAPGDYHPEKVRQDHNPAY---SFAGRHDLQKPDNTPAPG 600
                 |::   ||| ..:..||  .||.|....:       |::   ||...:...:|   ||.|
Yeast   553 -----PSFGTPSFG-SGNSSVE--PPASGSAFGK-------PSFGTPSFGSGNSSAEP---PASG 599

  Fly   601 AYFPEKVRLDHNPAFSMAGKYDAKVTNDTPAPGDYSPEKVRQDTNPAYSFAGRHDLHKPSETPA- 664
            :.|.:       |:|.            |.|.|..|    ..:||.. |..|:......|..||
Yeast   600 SAFGK-------PSFG------------TSAFGTAS----SNETNSG-SIFGKAAFGSSSFAPAN 640

  Fly   665 ------------PGAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGDYSPEKCRLD----HTPA 713
                        |...||::|  |....|              |:.||.|.::.:.|    .||
Yeast   641 NELFGSNFTISKPTVDSPKEV--DSTSPF--------------PSSGDQSEDESKSDVDSSSTP- 688

  Fly   714 YSFGGKNDPKVENNTPAPGDYHPEKVRLDHNPAYSFAGRHDLQKPSDTPAPGAYSPEKVRQDHNP 778
              ||.|.:...:..|                .|:.|..                      .....
Yeast   689 --FGTKPNTSTKPKT----------------NAFDFGS----------------------SSFGS 713

  Fly   779 AFSMAGKPVEKLTN---GTPAPGDYSPEKVRLNHTPAYTFGGKNDPKVENNTPAPGDYHPEKVRQ 840
            .||.|.:.|...|.   ||.|    ||...:|.:...::...|:|  .||.:.:.|.  ..::..
Yeast   714 GFSKALESVGSDTTFKFGTQA----SPFSSQLGNKSPFSSFTKDD--TENGSLSKGS--TSEIND 770

  Fly   841 DHNPAFSFAGRHDLHKPN--------------------DTPA--PGAYCPEKVRQDHNPAFSMAG 883
            |:.       .|:.:.||                    :||:  .|....|:.::      |..|
Yeast   771 DNE-------EHESNGPNVSGNDLTDSTVEQTSSTRLPETPSDEDGEVVEEEAQK------SPIG 822

  Fly   884 KYTQ---KVANDTPAPGDYSPEKVRLDHTPAYTFGGKNDPKVESNTPAPGDYHPEKVRQDHNPAF 945
            |.|:   |.||...| |..:|           .||  |..|.:|.:|                 |
Yeast   823 KLTETIKKSANIDMA-GLKNP-----------VFG--NHVKAKSESP-----------------F 856

  Fly   946 SFAGRHNLQKPSDTPAPGAYSPEKVRQDHNPAFTMAGKHDPKVSNDTPAPGDYSPEKVRLDYTPS 1010
            | |...|:.|||.|               .|||:.......|.:..|.:|.:.:..|...:..|
Yeast   857 S-AFATNITKPSST---------------TPAFSFGNSTMNKSNTSTVSPMEEADTKETSEKGP- 904

  Fly  1011 FTFAGKNNPKVENDTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPSDTPAPGAYSPEK--VRQDH 1073
            .|.....||.:    ||..:...|..::|||               |.|..|..|..:  ||...
Yeast   905 ITLKSVENPFL----PAKEERTGESSKKDHN---------------DDPKDGYVSGSEISVRTSE 950

  Fly  1074 NPAFSMAGKYIEK---ITNGTPAPGD--YCPEKVRLDHTPAFTFGGKNDPKVENNTPAPGDYHPE 1133
            :...:.|.:.|.|   :.|...:..|  |....| :||        .|..|..|.|....:...:
Yeast   951 SAFDTTANEEIPKSQDVNNHEKSETDPKYSQHAV-VDH--------DNKSKEMNETSKNNERSGQ 1006

  Fly  1134 K---VRQDHVPAFSFAGRHDLHKPNETPAPGAYSPEKVRQDHNPAFTMAGKHDPKVTHDTPAPGD 1195
            .   |:.|.:.         |.|.||.....:....|..:||..:...|.:.|.:.:.:.....|
Yeast  1007 PNHGVQGDGIA---------LKKDNEKENFDSNMAIKQFEDHQSSEEDASEKDSRQSSEVKESDD 1062

  Fly  1196 YHPEKVRLDHNPAFSFAGRHDLHKPSETPAPGDYFPEKVRQ-----DFNPAFT----FAGKHDPR 1251
            ........|.:.:.|:....|:: ..|.|..|:.|  |.|:     ||:...:    :|......
Yeast  1063 NMSLNSDRDESISESYDKLEDIN-TDELPHGGEAF--KAREVSASADFDVQTSLEDNYAESGIQT 1124

  Fly  1252 SLSESPAPGDYSPEKVRLDH 1271
            .||||....:...:.:.:.|
Yeast  1125 DLSESSKENEVQTDAIPVKH 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8086	NP_001260237.1	None
NUP159	NP_012151.1	NUP214	24..380	CDD:407023
		COG5651	142..673	CDD:227938	81/372 (22%)
		PTZ00395	<558..>874	CDD:185594	98/477 (21%)
		PRK08581	751..>1006	CDD:236304	73/347 (21%)
		MDN1	<892..1163	CDD:227596	59/294 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000