back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8086 and Nup98-96

DIOPT Version :9

Sequence 1:	NP_001260237.1	Gene:	CG8086 / 34131	FlyBaseID:	FBgn0032010	Length:	1603	Species:	Drosophila melanogaster
Sequence 2:	NP_001262885.1	Gene:	Nup98-96 / 42816	FlyBaseID:	FBgn0039120	Length:	1960	Species:	Drosophila melanogaster

Alignment Length:	1618	Identity:	310/1618 - (19%)
Similarity:	463/1618 - (28%)	Gaps:	519/1618 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 FGLKTK----HIQVSDTPAPGAYS-PEKS-----RLHSAPAYSIAGKASQDVVDCTPAPGAYEPE 341
            ||..|.    ....:...|.||:| |:::     ...:|.:.|:.|:::      .||.||.:|.
  Fly    73 FGANTSTGFGSTATAQPTAFGAFSQPQQTSNIFGSTQTAASTSLFGQST------LPAFGAAKPT 131

  Fly   342 KCVLSRTPAFS-----FGHRAELAKSSDTPAPGTYNPEKVRLDHTPAFTLSGRPETRSVSETPAP 401
            .....:|.|..     ||..|....::.....||..|....:..:...:...:|:..:|..:...
  Fly   132 MTAFGQTAAAQPTGSLFGQPAAATSTTGFGGFGTSAPTTTNVFGSGTASAFAQPQATAVGASGVN 196

  Fly   402 GSYAPEKYR-----------------NDRTPAFT----FGGK--HEQRLESSTPAPGDY-CPEKV 442
            ...|..||:                 |.:....|    |.||  .|.|||       || |..|.
  Fly   197 TGTAVAKYQPTIGTDTLMKSGQANSVNTKQHCITAMKEFEGKSLEELRLE-------DYMCGRKG 254

  Fly   443 RHDHNPAFSFAGRHDLHKPSDTPAPGAYDT----------EKVRQDH--------------NPAF 483
            ....|...:|.....:.:|:...:.|.:.:          :.|.::.              |.||
  Fly   255 PQAGNAPGAFGFGAQVTQPAQPASGGLFGSTAQPSTGLFGQTVTENKSMFGTTAFGQQPATNNAF 319

  Fly   484 SFAGRHD--LHK--------PSETPAPGAYSPEKVRQDHNPAFSMAGK--HSQKVTSDSPAPGDY 536
            ..|.:.:  |.|        |...||..|.:|...:    |||...|.  .....||.:||.|.
  Fly   320 GAATQQNNFLQKPFGATTTTPFAAPAADASNPFGAK----PAFGQGGSLFGQAPATSAAPAFGQ- 379

  Fly   537 CPEKVRLDHTPAYSFGVKSDPKVENN----TPAPGDYHPEKVRQDHNPAYSFAGR-HDLQKPDNT 596
                   .:|....||..:....::.    |||.   .|.|.......|.|.|.. .....|..:
  Fly   380 -------TNTGFGGFGTTAGATQQSTLFGATPAA---DPNKSAFGLGTAASAATTGFGFGAPATS 434

  Fly   597 PAPGAYFPEKVRLDHNPAFSMAG-KYDAKVTNDTPAPGDYSPEKVRQDTNPAYSFAG--RHDLHK 658
            .|.|..|..|      ||.|.|. .:.|..|..||.      .....:|:.|.:..|  ...|:|
  Fly   435 TAGGGLFGNK------PATSFAAPTFGATSTASTPF------SNFGLNTSTAATGGGLFNSGLNK 487

  Fly   659 PSETPAPGAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGD--YSPEKCRLDHTPA-------- 713
            |:.:...|..:.....|:.|     ||.....:...|..||.  :......|..|.|
  Fly   488 PATSGFGGFGATSAAPLNFN-----AGNTGGSLFGNTAKPGGGLFGGGTTTLGGTGAAPTGGLFG 547

  Fly   714 ---YSFGGKN-----------------------DPKVENNTPAPGDYHPEKVRLDHNPAYSFAGR 752
               .||||..                       .|.:...||:....|.:.:....:|.......
  Fly   548 GGTTSFGGVGGSLGGGGFGMGTNNSLTGGIMGAQPTLGIMTPSHQPIHQQILARVTSPYGDSPIF 612

  Fly   753 HDLQKPSDTPAPGAYSPEKVRQDHNPAFSMAGKPVEKLTNGTPAPGDYSPEKVRLNHTPAYTFGG 817
            .||:..|:..|..|.:|..    ......:.....:..|:..|||.........||....:....
  Fly   613 KDLKLSSEADATRATNPAA----QQAVLDLTSNQYKISTSNNPAPMKVKALGSTLNRKSLFDGLE 673

  Fly   818 KNDPKVENNTPAPGDYH---PEKVR--QDHNPAFSFAGRHDLHKPNDTP--APGAYCPEKVRQDH 875
            :.|..||.....|....   ..||:  :..||:.|...     .|| ||  .|....|.|.|:
  Fly   674 EFDASVEGFNLKPSAKRLVIKPKVKSVEGGNPSSSIGS-----APN-TPQSRPKGATPNKERE-- 730

  Fly   876 NPAFSMAGKYTQKVANDTPAPGDYSPEKVRLDHTPAYTFGGKNDPKVESNTPAPGDYHP---EKV 937
              :||.|      :.::...|...||             |..|..:.:.|.......||   |||
  Fly   731 --SFSGA------IPSEPLPPAGNSP-------------GATNGRESQDNGRRESWLHPNNLEKV 774

  Fly   938 RQDHNPAFSFAGRHNLQKPSDTPAP-----GAYSPEKVRQDHNPAFTMAGKHDPKVSNDTPAPGD 997
            ||           ||:|...|..:|     ....|.|....:.|:.|:      ::|..|.....
  Fly   775 RQ-----------HNIQTGMDQGSPHNSTLNELVPRKPLDTYRPSSTV------RLSVSTIPENP 822

  Fly   998 YSPEKVRLDYTPSFTFAGKNNPKVENDTPAPGDYHPEKVRQDHNPAFSFAGRHDLHKPSDTPAPG 1062
            :..:...:....:||....|...:.|.:....|....:.|.....|.:.|...:.|       |.
  Fly   823 FEDQSSTIARRETFTSQQANESVLSNRSNEAEDSAANQSRLAIEAAAAEAADDESH-------PT 880

  Fly  1063 AYSPEKVRQDHNPAFSMAGKYIEKITNGTPAPGDYCPEKVRLDHTPAFT----------FGGKND 1117
            .....:|.....|:......|:        |....|.       .|.||          ||.:.|
  Fly   881 GIVLRRVGYYTIPSLDDLRSYL--------AEDGSCV-------VPNFTVGREGYGNVFFGKEMD 930

  Fly  1118 --------------------PKVENNTP-APGDYHPEKVRQDHVPAFSFAGRHDLHKPN---ETP 1158
                                |..||..| ..|.....:|..|.|..........:..|.   |..
  Fly   931 VAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMD 995

  Fly  1159 APGAYSPEKVRQDHNPAFTMAGKHDPKVTHDTPAPGDYHPEKVRLDHNPAFSFAGRHDLHKPSET 1223
            ..|     |:|:       :..|:|.:.....|..|.:   ..|:.|   ||..|..|..:..|.
  Fly   996 WEG-----KLRR-------VCDKNDTRFIEYRPETGSW---VFRVKH---FSKYGLGDSDEEDEL 1042

  Fly  1224 PAPGDYFPEK---------------------VRQDFNPAFTFAGKHDPRSLSESPAPG----DYS 1263
            |..    |:|                     :||....:...|...||::|....|.|    |.:
  Fly  1043 PTD----PKKAKIATLEAQQRANAEKMTLNSLRQAQKISEDAARNLDPKALVAGVASGFRPMDDT 1103

  Fly  1264 PEKVRLDHAPAFSFGGKHD------PKTEHLHPAPC-------------------------DYAP 1297
            .|.:.:|....|..||..|      |:......:|.                         |.||
  Fly  1104 AEFLLMDKTQFFQAGGNSDFSMFDPPRQRPTITSPTAVLAQEMVGNEAHKMQLMKSSFFVEDNAP 1168

  Fly  1298 EKVRLDHT----------------------------------PAYTIAGRPAADHVSQTPAPCDY 1328
            |...::.|                                  ||.     |.:..||:....||.
  Fly  1169 EDEPMETTGRLLRHRKFFNVEPLVWKDGASESSSQYDFEHPSPAL-----PISSSVSEASLMCDA 1228

  Fly  1329 HPEQCQVDSTPAFTFGMRLGRERISDTPAPSAYEPEKHSLHSTPAYSFGTKSDI-----RVTTDA 1388
            |.|:....:|.:..                :|.:..|..:..|.|:.|..|..:     |.|| .
  Fly  1229 HYEETSSMATGSIV----------------AAVKETKFEMPVTKAFKFVCKPKVAPIKLRATT-V 1276

  Fly  1389 PAP---------------GHYHPEQCKLDSSPAYSF----------GLKTVPTASLP-----EPR 1423
            |.|               |.|.....||...|..|.          .||.....|||     .||
  Fly  1277 PLPRSIAYEMRDNWIADLGFYKGRSFKLSFGPQNSLVLPSTYNNMQNLKEFTGPSLPVSMVFAPR 1341

  Fly  1424 GAY--------------------IEDRIVQRRERRLASPVRNNAECTTTTTNHTNNNAGSSTTTT 1468
            .|.                    ..:.|:...|.:|...:..|.|.:.....|.::.
  Fly  1342 SATDLSPSVMQLVEFNMVKGNEGFRESIIPHLEVQLNDCLSVNVEGSECPCIHPDSG-------- 1398

  Fly  1469 TTTTTTTKTFINGVEQPELQKKETTK--------QVNGTHKEL----KSAPQAPLSNGNIVSN-- 1519
              |...:|.|...::|.....||...        .:.|.|.||    |::....:...|::|.
  Fly  1399 --TKLVSKHFSESLKQRNAGLKEDYSVSVWSLLFALWGDHDELVDLEKNSHYMVMCRRNLLSEWL 1461

  Fly  1520 -----GNH--SKMVSTTTRIQEV-----AHGQKES---------GNLKVVASGKSDAS 1556
                 |..  ||.|||.:.::.:     .|...|:         .||.:|.|..|..:
  Fly  1462 ENTLLGKDLLSKKVSTHSYLEHMLDLLSCHRVNEACELAFSYDDANLALVLSQLSSGA 1519

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.